merck millipore,默克密理愽
  • merck millipore,默克密理博,14-577M,Hck Protein, active, 250 µg

  • merck millipore,默克密理博,14-577M,Hck Protein, active, 250 µg

    产品名称：Hck Protein, active, 250 µg
    产品型号：14-577M
    Active, N-terminal His6-tagged, recombinant, human Hck, amino acids 230-497, for use in Kinase Assays.

    merck millipore,默克密理博,14-577M,Hck Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-577M,Hck Protein, active, 250 µg

    描述
    产品目录编号 14-577M
    品牌系列 Upstate
    商名
    • Upstate
    描述 Hck Protein, active, 250 µg
    概述 N-terminal His6-tagged, recombinant, human Hck, amino acids 230-497
    应用
    应用 Active, N-terminal His6-tagged, recombinant, human Hck, amino acids 230-497, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002110.2
    Entrez基因汇总 The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.
    基因符号
    • JTK9
    • HCK
    • p59-HCK/p60-HCK
    蛋白靶 Hck
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • P08631
    UniProt汇总 FUNCTION: SwissProt: P08631 # May serve as part of a signaling pathway coupling the Fc receptor to the activation of the respiratory burst. May also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.
    SIZE: 526 amino acids; 59600 Da
    SUBUNIT: May bind to HIV-1 Nef and VIF through its SH3 domain. This interaction would stimulates its tyrosine-kinase activity.
    SUBCELLULAR LOCATION: Isoform p59-HCK: Membrane; Lipid-anchor. & Isoform p60-HCK: Membrane; Lipid-anchor. Cytoplasm.
    TISSUE SPECIFICITY: Expressed predominantly in cells of the myeloid and B-lymphoid lineages.
    DOMAIN: SwissProt: P08631 The SH3 domain mediates binding to HIV-1 Nef.
    PTM: Isoform p59-HCK contains a N-myristoyl glycine at position 3 (By similarity). Isoform p59-HCK contains a S-palmitoyl cysteine at position 3 (By similarity).
    SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of Src substrate peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-577) and in bulk (cat# 14-577-K).

    merck millipore,默克密理博,14-577M,Hck Protein, active, 250 µg

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