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merck millipore,默克密理博,MABT472,Anti-Glypican-3, clone EPR5547, Rabbit Monoclonal Antibody
产品名称：Anti-Glypican-3, clone EPR5547, Rabbit Monoclonal Antibody
产品型号：MABT472
This Anti-Glypican-3, clone EPR5547, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Immunofluorescence for the detection of Glypican-3.
merck millipore,默克密理博,MABT472,Anti-Glypican-3, clone EPR5547, Rabbit Monoclonal Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Unpurified Monoclonal Antibody 描述 产品目录编号 MABT472 描述 Anti-Glypican-3, clone EPR5547, Rabbit Monoclonal Antibody Alternate Names - MXR7
- Glypican-3
- GTR2-2
- Intestinal protein OCI-5
背景信息 Glypican-3, also known as GTR2-2, and encoded by the gene GPC3, is a cell surface heparin sulfate containing glycoprotein that plays an important role in the modulation of growth and development of mesodermal tissues and organs, as well as various cancers. Among its many known functions, it is a regulator of the dipeptidyl peptidase DPP4 (CD26). DPP4 plays an important role in glucose metabolism via its action on incretin and GLP-1 hormones. DPP4 also is a cancer marker and thought to function as a cancer suppressor. Thus acting as a regulator of DPP4, Glypican-3 participates in everything from glucose and blood sugar regulation to tumor growth. Glypican-3 is most highly expressed in the lung, liver and kidney, and typically a secreted form, secreted glypican-3, is found in the extracellular space generated as a cleavage product by the action of a convertase. Defects in Glypican-3 cause Simpson-Golabi-Behmel syndrome type 1 (SGBS1) or Simpson dysmorphia syndrome (SDYS). This is a condition characterized by pre-and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. 产品信息 格式 Unpurified 演示 Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol. 应用 应用 This Anti-Glypican-3, clone EPR5547, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Immunofluorescence for the detection of Glypican-3. 主要应用 - Western Blotting
应用说明 Immunofluorescence Analysis: A 1:100-250 dilution from a representative lot detected Glypican-3 in HepG2 cells.
Produced in collaboration with Epitomics™生物信息 免疫原品种 Synthetic peptide corresponding to human Glypican-3. 克隆 EPR5547 浓缩 Please refer to lot specific datasheet. 宿主 Rabbit 同种型 IgG 品种反应性 Human Species Reactivity Note Human 抗体类型 Monoclonal Antibody 基因符号 - OCI5
- GPC3
纯化方法 Unpurified UniProt编号 - P51654
产品使用声明 质量保证 Evaluated by Western Blotting in SH-SY5Y, Jurkat, and HepG2 cell lysates.
Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected Glypican-3 in SH-SY5Y, Jurkat, and HepG2 cell lysates.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.包装信息 数量 100 µL
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