merck millipore,默克密理愽
  • merck millipore,默克密理博,AB2281,Anti-Na+K+Cl- Cotransporter 2 Antibody

  • merck millipore,默克密理博,AB2281,Anti-Na+K+Cl- Cotransporter 2 Antibody

    产品名称：Anti-Na+K+Cl- Cotransporter 2 Antibody
    产品型号：AB2281
    Anti-Na+K+Cl-Cotransporter 2 Antibody detects level of Na+K+Cl-Cotransporter 2 & has been published & validated for use in WB.

    merck millipore,默克密理博,AB2281,Anti-Na+K+Cl- Cotransporter 2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB2281,Anti-Na+K+Cl- Cotransporter 2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, R, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB2281
    描述 Anti-Na+K+Cl- Cotransporter 2 Antibody
    Alternate Names
    • solute carrier family 12 (sodium/potassium/chloride<br />transporters), member 1
    • Bumetanide-sensitive sodium-(potassium)-chloride<br />cotransporter 2
    • Kidney-specific Na-K-Cl symporter
    • NKCC2A variant A
    • Na-K-2Cl cotransporter
    • sodium potassium chloride cotransporter 2
    • solute carrier family 12 (sodium/potassium/chloride<br />transporters)
    背景信息 The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. SLC12A1 is kidney specific and is essential in the regulation of ionic balance and cell volume. It is a component of an electrically silent transporter system, mediating sodium and chloride reabsorption. Defects in SLC12A1 are the cause of Bartter syndrome type 1, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria.
    产品信息
    格式 Affinity Purified
    控制
    • Rat liver lysates
    演示 Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
    应用
    应用 Anti-Na+K+Cl-Cotransporter 2 Antibody detects level of Na+K+Cl-Cotransporter 2 & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH conjugate followed by NA+K+CL- Cotransporter 2 corresponding to the cytoplasmic domain.
    表位 Cytoplasmic domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the cytoplasmic domain of NA+K+CL- Cotransporter 2.
    品种反应性 HumanRatMouse
    Species Reactivity Note Proven to react with human, rat and mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000338.2
    Entrez基因汇总 The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. [provided by RefSeq].
    基因符号
    • NKCC2
    • SLC12A1
    • BSC1
    • MGC48843
    纯化方法 Antigen affinity purified
    UniProt编号
    • Q13621
    UniProt汇总 FUNCTION: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.

    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

    TISSUE SPECIFICITY:Kidney specific.

    DISEASE: Defects in SLC12A1 are the cause of Bartter syndrome type 1 (BS1) [MIM:601678]. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS1 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS1 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia. Ref.1

    SIMILARITIY: Belongs to the SLC12A transporter family.
    产品使用声明
    质量保证 Western Blot Analysis:
    1:2,000 dilution of this lot detected NA+K+CL- Cotransporter 2 on 10 µg of rat liver lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8ºC from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB2281,Anti-Na+K+Cl- Cotransporter 2 Antibody

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