merck millipore,默克密理愽
  • merck millipore,默克密理博,04-384,Anti-phospho-MSK1 (S376) Antibody, rabbit monoclonal

  • merck millipore,默克密理博,04-384,Anti-phospho-MSK1 (S376) Antibody, rabbit monoclonal

    产品名称：Anti-phospho-MSK1 (S376) Antibody, rabbit monoclonal
    产品型号：04-384
    Anti-phospho-MSK1 (S376) Antibody is an antibody against phospho-MSK1 (S376) for use in FC, IH(P), IP & WB.

    merck millipore,默克密理博,04-384,Anti-phospho-MSK1 (S376) Antibody, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-384,Anti-phospho-MSK1 (S376) Antibody, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, FCRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-384
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-MSK1 (S376) Antibody, rabbit monoclonal
    Alternate Names
    • Ribosomal protein S6 kinase
    产品信息
    格式 Purified
    控制
    • POSITIVE: K562 cells.
    演示 Rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
    应用
    应用 Anti-phospho-MSK1 (S376) Antibody is an antibody against phospho-MSK1 (S376) for use in FC, IH(P), IP & WB.
    主要应用
    • Western Blotting
    • Flow Cytometry
    应用说明 Western Blot: 1:5000.
    Immunoprecipitation: 1:30.
    Immunofluorescence: 1:100-1:250.
    Immunohistochemistry: 1:50-1:100 on paraffin-embedded sections of human urinary bladder carcinoma.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 KLH-conjugated synthetic phospho-peptide corresponding to residues surrounding Serine 376 of human MSK1.
    宿主 Rabbit
    特异性 Recognizes MSK1 when phosphorylated on Ser376.
    同种型 IgG
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_182398.1
    • NM_004755.2
    基因符号
    • RPS6KA5
    • RLPK
    • MGC1911
    • MSPK1
    • RSKL
    • MSK1
    修改
    • Phosphorylation
    UniProt编号
    • O75582
    UniProt汇总 FUNCTION: SwissProt: O75582 # Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
    COFACTOR: Magnesium.
    SIZE: 802 amino acids; 89865 Da
    SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.
    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear. Partially cytoplasmic.
    TISSUE SPECIFICITY: Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
    PTM: Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C- terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain.
    SIMILARITY: SwissProt: O75582 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
    MISCELLANEOUS: Enzyme activity requires the presence of both kinase domains.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot analysis.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C from date of shipment.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-384,Anti-phospho-MSK1 (S376) Antibody, rabbit monoclonal

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