merck millipore,默克密理愽
  • merck millipore,默克密理博,17-127,Ser/Thr Phosphatase Assay Kit 1 (K-R-pT-I-R-R)

  • merck millipore,默克密理博,17-127,Ser/Thr Phosphatase Assay Kit 1 (K-R-pT-I-R-R)

    产品名称：Ser/Thr Phosphatase Assay Kit 1 (K-R-pT-I-R-R)
    产品型号：17-127
    Ser/Thr Phosphatase Assay Kit 1used to detect PP2A activity by either dephosphorylation of the phosphopeptide.

    merck millipore,默克密理博,17-127,Ser/Thr Phosphatase Assay Kit 1 (K-R-pT-I-R-R)

  • 产品介绍
  • merck millipore,默克密理博,17-127,Ser/Thr Phosphatase Assay Kit 1 (K-R-pT-I-R-R)

    重要规格表

    主要应用 可用的分析物 检测方法
    PASer/Thr KinasesColorimetric
    描述
    产品目录编号 17-127
    品牌系列 Upstate
    商名
    • Upstate
    描述 Ser/Thr Phosphatase Assay Kit 1 (K-R-pT-I-R-R)
    产品信息
    部件
    • 96-well microtiter plate
    • Malachite Green Solution A (Cat.# 20-105)
    • Malachite Green Additive (Cat.# 20-104)
    • Phosphate Standard (Cat.# 20-103)
    • Threonine Phosphopeptide (K-R-pT-I-R-R) (Cat.# 12-219)
    • pNPP (p-Nitrophenyl Phosphate) (Cat.# 20-106)
    • pNPP Ser/Thr Assay Buffer (Cat.# 20-179)
    • NiCl2, 40mM (Cat.# 20-178)
    检测方法 Colorimetric
    应用
    应用 Ser/Thr Phosphatase Assay Kit 1used to detect PP2A activity by either dephosphorylation of the phosphopeptide.
    主要应用
    • Phosphatase Assay
    生物信息
    可用的分析物
    • Ser/Thr Kinases
    Entrez基因编号
    • NM_181699.2
    • NM_002716.4
    Entrez基因汇总 This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • PR65B
    • PPP2R1B
    • PP2A-A-beta
    • MGC26454
    UniProt编号
    • P30154
    UniProt汇总 FUNCTION: SwissProt: P30154 # The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
    SIZE: 601 amino acids; 66214 Da
    SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9.
    DOMAIN: SwissProt: P30154 Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
    DISEASE:SwissProt: P30154 # Defects in PPP2R1B might be a cause of some lung and colorectal cancers.
    SIMILARITY: Belongs to the phosphatase 2A regulatory subunit A family. & Contains 15 HEAT repeats.
    产品使用声明
    质量保证 routinely used to detect PP2A (Catalog # 14-111) activity by either dephosphorylation of the phosphopeptide (K-R-pT-I-R-R) or hydrolysis of pNPP
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 1 kit
    包装 Kit capacity: 100 assays

    merck millipore,默克密理博,17-127,Ser/Thr Phosphatase Assay Kit 1 (K-R-pT-I-R-R)

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