merck millipore,默克密理博,MABT207,Anti-Integrin alpha-V Antibody, clone 272-17E6 (Azide free)

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merck millipore,默克密理博,MABT207,Anti-Integrin alpha-V Antibody, clone 272-17E6 (Azide free)
产品名称：Anti-Integrin alpha-V Antibody, clone 272-17E6 (Azide free)
产品型号：MABT207
Anti-Integrin alpha-V Antibody, clone 272-17E6 (Azide free) detects level of Integrin alpha-V & has been published & validated for use in Flow Cytometry, Immunoprecipitation, Activity Assay.

merck millipore,默克密理博,MABT207,Anti-Integrin alpha-V Antibody, clone 272-17E6 (Azide free)

产品介绍

merck millipore,默克密理博,MABT207,Anti-Integrin alpha-V Antibody, clone 272-17E6 (Azide free)

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	ACT, FC	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABT207
描述	Anti-Integrin alpha-V Antibody, clone 272-17E6 (Azide free)
Alternate Names	Intergrin av Integrin alpha-V Vitronectin receptor subunit alpha CD51 Integrin alpha-V heavy chain Integrin alpha-V light chain
背景信息	Integrin alpha-V (or CD51; vitronectin receptor subunit alpha) protein is a transmembrane receptor that mediates adhesion of cells to each other and to the extracellular matrix. Integrin receptors are activated by a variety of intracellular signals that modify its cytoplasmic domain and induce configural changes in integrin molecules thereby enabling ligand binding to the extracellular surface. An important part of this process is the binding of the actin protein, talin, to the integrin cytoplasmic domain.

产品信息
格式	Purified
控制	HeLa cells
演示	Purified mouse monoclonal IgG1κ in buffer containing PBS without preservative.

应用
应用	Anti-Integrin alpha-V Antibody, clone 272-17E6 (Azide free) detects level of Integrin alpha-V & has been published & validated for use in Flow Cytometry, Immunoprecipitation, Activity Assay.
主要应用	Activity Assay Flow Cytometry
应用说明	Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to detect Integrin alpha-V in M21 cell lysates. (Mitjans, F., et al (1995). Journal of Cell Science. 108:2825-2838.)

生物信息
免疫原品种	Human Placental ɑvβ3
克隆	272-17E6
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
同种型	IgG1κ
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_001138472
Entrez基因汇总	ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple script variants. [provided by RefSeq, Feb 2009].
基因符号	VNRA ITGAV MSK8
纯化方法	Protein G purified
UniProt编号	P06756
UniProt汇总	FUNCTION: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. SUBNUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. Interacts with RAB25. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SEQUENCE SIMILARITIES: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. SEQUENCE CAUTION: The sequence BAD93131.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

产品使用声明
质量保证	Evaluated by Flow Cytometry in HeLa cells. Flow Cytometry Analysis: 0.5 µg of this antibody detected Integrin alpha-V in HeLa cells.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.