merck millipore,默克密理博,07-844,Anti-phospho-IRS1 (Tyr1179) Antibody

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merck millipore,默克密理博,07-844,Anti-phospho-IRS1 (Tyr1179) Antibody
产品名称：Anti-phospho-IRS1 (Tyr1179) Antibody
产品型号：07-844
Detect phospho-IRS1 (Tyr1179) using this anti-phospho-IRS1 (Tyr1179) Antibody validated for use in WB.

merck millipore,默克密理博,07-844,Anti-phospho-IRS1 (Tyr1179) Antibody

产品介绍

merck millipore,默克密理博,07-844,Anti-phospho-IRS1 (Tyr1179) Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-844
品牌系列	Upstate
商名	Upstate
描述	Anti-phospho-IRS1 (Tyr1179) Antibody
Alternate Names	IRS-1, Insulin Receptor Substrate-1 IRS-1

产品信息
格式	Affinity Purified
演示	100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.

应用
应用	Detect phospho-IRS1 (Tyr1179) using this anti-phospho-IRS1 (Tyr1179) Antibody validated for use in WB.
主要应用	Western Blotting
应用说明	Immunoblot Analysis: A 1:1000 dilution of this lot detected phospho-IRS1 (Tyr1179) in RIPA lysates from insulin stimulated IRS1 transfected CHO cells.

生物信息
免疫原品种	Peptide corresponding to the amino acid region encompassing the human phospho-IRS1(Tyr1179). Sequence widely conserved among multiple species.
宿主	Rabbit
特异性	Human IRS1 (Insulin Receptor Substrate 1) phosphorylated on Tyrosine residue 1179. Sequence highly homologous with mouse, rat, and chicken.
同种型	IgG
品种反应性	RatHumanMouse
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_005544.1
基因符号	HIRS-1 IRS1 IRS-1
修改	Phosphorylation
纯化方法	Affinity Purfied
UniProt编号	P35568
UniProt汇总	FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). SIZE: 1242 amino acids; 131591 Da SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7. PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 2 years at -20°C from date of shipment. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 2 years at -20°C from date of shipment.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.