merck millipore,默克密理博,MABS387,Anti-Apolipoprotein Antibody L1, clone EPR2906, rabbit monoclonal

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merck millipore,默克密理博,MABS387,Anti-Apolipoprotein Antibody L1, clone EPR2906, rabbit monoclonal
产品名称：Anti-Apolipoprotein Antibody L1, clone EPR2906, rabbit monoclonal
产品型号：MABS387
Detect Apolipoprotein using this rabbit monoclonal antibody, Anti-Apolipoprotein Antibody L1, clone EPR2906 validated for use in western blotting & IHC.

merck millipore,默克密理博,MABS387,Anti-Apolipoprotein Antibody L1, clone EPR2906, rabbit monoclonal

产品介绍

merck millipore,默克密理博,MABS387,Anti-Apolipoprotein Antibody L1, clone EPR2906, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABS387
描述	Anti-Apolipoprotein Antibody L1, clone EPR2906, rabbit monoclonal
Alternate Names	ApoL-I Apolipoprotein L1 Apolipoprotein L Apo-L ApoL Apolipoprotein L-I
背景信息	Apolipoprotein L1/Apolipoprotein L-1 (ApoL-1), or alternatively Apolipoprotein L (Apo-L/ApoL) is the protein encoded by the APOL1 gene in humans. Apolipoprotein L1 is one of the major carriers of cholesterol in the blood. It plays a role in the transport of cholesterol from the peripheral cells to the liver. It is a secreted protein expressed in liver, pancreas, lung, prostate, placenta and spleen. Apolipoprotein L1 is part of the HDL (high density lipoprotein) complex and Apolipoprotein L1 possesses both extra- and intra-cellular functions crucial in host defense and cellular homeostatic mechanisms. Alterations in Apolipoprotein L1 function due to genetic, environmental, and lifestyle factors have been associated with African sleeping sickness, atherosclerosis, lipid disorders, obesity, schizophrenia, cancer, and chronic kidney disease (CKD), yet much of its biological function remains unknown. Interesting, Apolipoprotein L1 has the ability to kill circulating trypanosomes in the blood. Trypanosomes cause a serious disease called sleeping sickness but in those individuals that have particular splice variants of Apolipoprotein L1 are spared sleeping sickness, however the variants are associated with an increased chance of kidney disease as a tradeoff. Apolipoprotein L1 appears important in autophagy and even as a cancer preventative as well. Recent research shows that increased intracellular levels of Apolipoprotein L1 can induce autophagy and autophagy-associated cell death but that Apolipoprotein L1 may protect kidney cells against renal cell carcinoma. EMD-Millipore’s Anti-Apolipoprotein L1 rabbit monoclonal antibody has been tested in western blot using human plasma and ovary cancer lysates and in paraffin embedded immunohistochemistry on human liver tissue sections.

产品信息
格式	Unpurified
控制	Human plasma and ovary cancer tissue lysates
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	Detect Apolipoprotein using this rabbit monoclonal antibody, Anti-Apolipoprotein Antibody L1, clone EPR2906 validated for use in western blotting & IHC.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:100-250 dilution from a representative lot detected Apolipoprotein L1 in human liver tissue. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic peptide corresponding to human Apolipoprotein L1.
克隆	EPR2906
宿主	Rabbit
品种反应性	Human
抗体类型	Monoclonal Antibody
基因符号	APOL APOL1
纯化方法	Unpurified
UniProt编号	O14791

产品使用声明
质量保证	Evaluated by Western Blotting in human plasma and ovary cancer tissue lysates. Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected Apolipoprotein L1 in human plasma and ovary cancer tissue lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.