merck millipore,默克密理博,MABS179,Anti-Thioredoxin Reductase 2 Antibody, clone 1C4

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	WB	R	Purified	Monoclonal Antibody

描述
产品目录编号	MABS179
描述	Anti-Thioredoxin Reductase 2 Antibody, clone 1C4
Alternate Names	Thioredoxin reductase TR3 Thioredoxin reductase 2, mitochondrial
背景信息	Respiring mitochondria continuously produce H2O2. When production exceeds scavenging, H2O2 levels rise to a state, which can endanger cellular functions. The mitochondrial peroxidase peroxiredoxin-3 reduces H2O2 into water by utilizing reducing equivalents from NADPH supplied by Thioredoxin 2 (Trx2) and, ultimately, Thioredoxin Reductase 2 (TrxR2). Inhibition of TrxR2 has been shown to disturb mitochondrial redox balance, increase H2O2 emission, and ultimately contribute to cardiac dysfunction.

产品信息
格式	Purified
控制	NIH3T3 cell lysate
演示	Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	This Anti-Thioredoxin Reductase 2 Antibody, clone 1C4 is validated for use in WB for the detection of Thioredoxin Reductase 2.
主要应用	Western Blotting
应用说明	Western Blot Analysis: 0.5 µg/mL from a representative lot detected Thioredoxin Reductase 2 in mouse liver tissue lysate. Western Blot Analysis: 0.5 µg/mL from a representative lot detected Thioredoxin Reductase 2 in mouse kidney tissue lysate.

生物信息
免疫原品种	Linear peptide corresponding to mouse Thioredoxin Reductase 2.
克隆	1C4
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rat
同种型	IgG2aκ
品种反应性	Mouse
Species Reactivity Note	Demonstrated to react with Mouse.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_038739
Entrez基因汇总	This gene product belongs to the family of pyridine nucleotide-disulfide oxidoreductases. It is a mitochondrial enzyme that catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. This protein contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
基因符号	Trxr2 Txnrd2
纯化方法	Protein G Purified
UniProt编号	Q9JLT4
UniProt汇总	FUNCTION: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling. CATALYTIC ACTIVITY: Thioredoxin + NADP+ = thioredoxin disulfide + NADPH. COFACTOR: FAD. SUBUNIT STRUCTURE: Homodimer. SUBCELLULAR LOCATION: Mitochondrion. TISSUE SPECIFICITY: Expressed in liver, heart, testis and kidney.

产品使用声明
质量保证	Evaluated by Western Blot in NIH3T3 cell lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected Thioredoxin Reductase 2 in 10 µg of NIH3T3 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABS179,Anti-Thioredoxin Reductase 2 Antibody, clone 1C4

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