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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB10613 Replaces MABN1035 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-PSMA (NT) Antibody Alternate Names - Prostate Specific Membrane Antigen
背景信息 PSMA (prostate specific membrane antigen) is a type II, integral membrane glycoprotein, composed of a 19 amino acid intracellular domain containing the N-terminus, a 24 amino acid transmembrane region, and a 707 amino acid extracellular C-terminal domain. The PSMA gene has been cloned and sequenced, and has been localized to chromosome 11q. PSMA is highly expressed in prostate secretory-acinar epithelium, in some benign extraprostatic epithelial cells from breast, duodenum, and kidney tissues, and in prostate cancer. On the basis of its highly prostate-specific nature, PSMA has been used as a prostate cancer marker antigen and diagnostic target for prostate cancer detection. Recently, evidence of limited and specific endothelial PSMA expression has been discovered: the neovasculature of a wide variety of malignant neoplasms (lung, colon, breast, etc.) demonstrates PSMA expression. This finding suggests that PSMA may be an effective target for monoclonal antibody-based anti-neovasculature therapy. PSMA has also been identified in the human nervous system. Based on activity, immunoreactivity, and mRNA sequence comparison with one form of NAALADase, a neuropeptide that may modulate glutaminergic transmission in the nervous system, PSMA was found to be indistinguishable from NAALADase derived from human cerebellar cell isolates. Therefore, the form of NAALADase also known as PSMA is expressed in brain, where it makes up a significant fraction of brain NAALADase activity. 产品信息 格式 Purified 演示 This polyclonal antibody is supplied as a 400 μL aliquot in phosphate buffered saline (pH 7.4) containing 0.1% sodium azide. 应用 应用 Anti-PSMA (N-Terminal) Antibody is an antibody against PSMA (N-Terminal) for use in WB. 主要应用 - Western Blotting
应用说明 Western Blotting: 1-3 μg/mL 生物信息 免疫原品种 Synthetic peptide derived from the N-terminus of human PSMA. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes PSMA (N-Terminal). 品种反应性 Human Species Reactivity Note Human (positive control: LNCaP FGC cells) 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_148976.1
- NM_002786.2
Entrez基因汇总 The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome. 基因符号 - MGC14575
- PSMA1
- MGC22853
- MGC14751
- PROS30
- HC2
- PROS-30
- MGC1667
- MGC21459
- PSC2
- MGC14542
- MGC23915
- NU
纯化方法 Immunoaffinity purified UniProt编号 - O14818
- P25786
- P25787
- P25788
- P28066
- P60900
UniProt汇总 FUNCTION: SwissProt: P60900 # The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
SIZE: 246 amino acids; 27399 Da
SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
SIMILARITY: SwissProt: P60900 ## Belongs to the peptidase T1A family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20°C in undiluted aliquots for 1 year from date of shipment. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,AB10181,Anti-Pumilio-2 (PUM2) Antibody
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