merck millipore,默克密理愽
  • merck millipore,默克密理博,654164,Tubulin Polymerization Inhibitor II

  • merck millipore,默克密理博,654164,Tubulin Polymerization Inhibitor II

    产品名称：Tubulin Polymerization Inhibitor II
    产品型号：654164
    The Tubulin Polymerization Inhibitor II, also referenced under CAS 1151995-69-5, acts as an effective anti-microtubule agent. This small molecule/inhibitor is primarily used for Cell Structure applica More>>

    merck millipore,默克密理博,654164,Tubulin Polymerization Inhibitor II

  • 产品介绍
  • merck millipore,默克密理博,654164,Tubulin Polymerization Inhibitor II

    重要规格表

    经验配方 CAS号
    C₁₉H₁₉NO₅1151995-69-5
    描述
    概述 A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50 <10 nM for 46 lines among a 53 NCI panel tested).
    产品目录编号 654164
    品牌系列 Calbiochem®
    同义词 (E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one
    参考
    参考 Pandit, B., et al. 2006. Bioorg. Med. Chem. 14, 6492.
    Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5382.
    产品信息
    CAS号 1151995-69-5
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₁₉H₁₉NO₅
    化学配方 C₁₉H₁₉NO₅
    Molar Mass 341.4
    可逆 N
    结构配方图像
    生物信息
    主靶 Purified porcine brain tubulin
    主靶IC50 4.5 µM in inhibiting polymerization of purified porcine brain tubulin
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,654164,Tubulin Polymerization Inhibitor II

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