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merck millipore,默克密理博,MAB430,Anti-Epithelium/Endothelial Cells Antibody, clone 18.29 (PHM-5)
产品名称：Anti-Epithelium/Endothelial Cells Antibody, clone 18.29 (PHM-5)
产品型号：MAB430
Anti-Epithelium/Endothelial Cells Antibody, clone 18.29 (PHM-5) detects level of Epithelium/Endothelial Cells & has been published & validated for use in IH, IH(P).
merck millipore,默克密理博,MAB430,Anti-Epithelium/Endothelial Cells Antibody, clone 18.29 (PHM-5)
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC M Purified Monoclonal Antibody 描述 产品目录编号 MAB430 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Epithelium/Endothelial Cells Antibody, clone 18.29 (PHM-5) Alternate Names - Podocalyxin
- PCX
背景信息 The endothelium is the layer of thin specialized epithelium, comprising a simple squamous layer of cells that line the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall (simple squamous epithelium). Endothelial cells line the entire circulatory system, from the heart to the smallest capillary.
Endothelial cells are involved in many aspects of vascular biology, such as vasoconstriction and vasodilation, and hence the control of blood pressure; blood clotting (thrombosis & fibrinolysis); atherosclerosis; formation of new blood vessels (angiogenesis) and inflammation and swelling (oedema). Endothelial cells also control the passage of materials, and the transit of white blood cells, into and out of the bloodstream.产品信息 格式 Purified 控制 - HUVEC cells
- Kidney glomerulus tissue
演示 Liquid in PBS, pH 7.4, with 0.2% BSA and 0.1% sodium azide. 应用 应用 Anti-Epithelium/Endothelial Cells Antibody, clone 18.29 (PHM-5) detects level of Epithelium/Endothelial Cells & has been published & validated for use in IH, IH(P). 主要应用 - Immunohistochemistry
应用说明 Immunohistochemistry: 1:20-1:40 (immunoperoxidase). The antigen is stable to heat and trypsin but not neuraminidase digestion. Suitable for use on tissue processed by all routine fixing and embedding techniques.
Immunohistochemistry on paraffin embedded tissues: trypsin digestion or HEIR antigen retrieval suggested.
Optimal working dilutions must be determined by end user.生物信息 克隆 18.29 (PHM-5) 宿主 Mouse 特异性 Detects a human specific cell surface carbohydrate antigen (MW 165-170 kD) on all endothelial and selected epithelial cells. MAB430 reacts with epithelial cells in the breast salivary gland, pancreas and glomerulus. No reaction to epithelial cells in the bowel, skin and proximal tubule. The antigen recognized appears to be the sialoprotein podocalyxin protein 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005397.3
- NM_001018111.2
Entrez基因汇总 This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. 基因符号 - PCLP1
- PODXL
- MGC138240
- PCLP
- podocalyxin-like
- Gp200
UniProt编号 - O00592
UniProt汇总 FUNCTION: SwissProt: O00592 # Functions as an antiadhesin that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion.
SIZE: 528 amino acids; 55596 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Glomerular epithelium cell (podocyte).
PTM: Glycosylated; contains sialic acid.
SIMILARITY: SwissProt: O00592 ## Belongs to the podocalyxin family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 500 µL
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