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merck millipore,默克密理博,MABN712,Anti-CCL2 Antibody, clone 2D8
产品名称：Anti-CCL2 Antibody, clone 2D8
产品型号：MABN712
Detect Monocyte Chemotactic Protein using this mouse monoclonal antibody, Anti-CCL2 Antibody, clone 2D8 validated for use in western blotting, Immunofluorescence, IHC & Flow Cytometry.
merck millipore,默克密理博,MABN712,Anti-CCL2 Antibody, clone 2D8
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Mk, H, M, R FC, WB, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MABN712 描述 Anti-CCL2 Antibody, clone 2D8 Alternate Names - Small-inducible cytokine A2
- C-C motif chemokine 2
- Monocyte chemoattractant protein 1
- Monocyte chemotactic and activating factor
- Monocyte chemotactic protein 1
- Monocyte secretory protein JE
背景信息 CCL2, Chemokine (C-C motif) ligand 2, or alternatively known as Monocyte chemotactic protein 1 (MCP-1), Monocyte chemotactic and activating factor (MCAF), Monocyte chemoattractant protein 1, Monocyte secretory protein JE, Small-inducible cytokine A2, HC11, and C-C motif chemokine 2 is encoded by the human gene named CCL2/MCP1/SCYA2. CCL2 is a chemokine produced by endothelial cells that attracts memory T cells, monocytes, dendritic cells, and basophils but not neutrophils or eosinophils to sites of inflammation produced by either tissue inquiry or infection. CCL2 also bolsters monocytes anti-tumor activity, and because it is chemotactic for monocytes, CCL2 has been implicated in inflammatory diseases where monocytic invasions have occurred such as in psoriasis, rheumatoid arthritis and atherosclerosis. CCL2 is a bifunctional molecule as well; the whole molecule is a basophil activator but removal of the N-terminal portion converts the molecule into an exclusive eosinophil chemoattractant. CCL2 can also be found expressed at the sites of tooth eruption and bone degradation and is expressed by both osteoclasts and osteoblasts. CCL2 is also expressed in neurons, astrocytes and microglia and its role in neuroinflammation is established. CCL2 expression in glial and neurons is increased in epilepsy, brain ischemia, Alzheimer’s disease, brain injury and experimental autoimmune encephalomyelitis. Finally, CCL2 plays a role in vascular complications associated with type II diabetes and in the production of amylin which contributes to insulin resistance in obesity, which is also associated with type II diabetes. EMD-Millipore’s Anti-CCL2 mouse monoclonal antibody has been tested in western blot against recombinant protein and cell lysates from A549, HeLa, Raw264.7, L1210, C6, and COS7 cell lines. 产品信息 格式 Purified 控制 - A549, HeLa, Raw264.7, L1210, C6 and COS-7 cell lysates
演示 Purified mouse monoclonal in PBS with up to 0.1% sodium azide and 0.5% protein stabilizer. 应用 应用 Detect Monocyte Chemotactic Protein using this mouse monoclonal antibody, Anti-CCL2 Antibody, clone 2D8 validated for use in western blotting, Immunofluorescence, IHC & Flow Cytometry. 主要应用 - Flow Cytometry
- Western Blotting
- Immunohistochemistry
应用说明 Immunofluorescence Analysis: A 1:200-1,000 dilution from a representative lot detected CCL2 in HeLa cells.
Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected CCL2 in human liver cancer tissue.
Flow Cytometry Analysis: A 1:200-400 dilution from a representative lot detected CCL2 in A549 cells.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Purified recombinant fragment of human CCL2 expressed in E. Coli. 克隆 2D8 宿主 Mouse 同种型 IgG1 品种反应性 MonkeyHumanMouseRat 抗体类型 Monoclonal Antibody 基因符号 - HSMCR30
- HC11
- MCAF
- MCP1
- MCP-1
- SCYA2
- GDCF-2
- SMC-CF
纯化方法 Unpurified UniProt编号 - P13500
产品使用声明 质量保证 Evaluated by Western Blotting in A549, HeLa, Raw264.7, L1210, C6 and COS-7 cell lysates.
Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected CCL2 in A549, HeLa, Raw264.7, L1210, C6 and COS-7 cell lysates使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,SCGVU10RE,Stericup-GV，0.22 µm，PVDF，500/1000 mL，射线灭菌
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