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描述 产品目录编号 14-548M 品牌系列 Upstate
商名 - Upstate
描述 MSK1 Protein, active, 250 µg 概述 N-terminal His6-tagged recombinant human MSK1 residues 2-end 应用 应用 Active, N-terminal His6-tagged recombinant human MSK1 residues 2-end, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 Expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_182398.1
- NM_004755.2
基因符号 - MSPK1
- RPS6KA5
- RSKL
- RLPK
- MGC1911
- MSK1
蛋白靶 MSK1 纯化方法 Ni2+/NTA-agarose 靶子系列 AGC UniProt编号 - O75582
UniProt汇总 FUNCTION: SwissProt: O75582 # Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
COFACTOR: Magnesium.
SIZE: 802 amino acids; 89865 Da
SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear. Partially cytoplasmic.
TISSUE SPECIFICITY: Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
PTM: Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C- terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain.
SIMILARITY: SwissProt: O75582 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
MISCELLANEOUS: Enzyme activity requires the presence of both kinase domains.产品使用声明 质量保证 routinely evaluated by phosphorylation of Crosstide 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -20°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-548) and in bulk (cat# 14-548-K).
上一件merck millipore产品：merck millipore,默克密理博,04-1151,Anti-Cyclin D1 Antibody, clone EPR2241(IHC)-32, rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,SCGVU10RE,Stericup-GV，0.22 µm，PVDF，500/1000 mL，射线灭菌
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