merck millipore,默克密理博,MABN310,Anti-G-protein coupled receptor 56 (GPR56) Antibody, clone H11

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	IHC, WB, ICC	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABN310
描述	Anti-G-protein coupled receptor 56 (GPR56) Antibody, clone H11
Alternate Names	G-protein coupled receptor 56 G protein-coupled receptor 56 7-transmembrane protein with no EGF-like N-terminal domains-1 Protein TM7XN1
背景信息	G-protein coupled receptor 56 (GPR56) is a ubiquitous adhesion receptor, which belongs to the G-protein coupled receptor 2 family and LN-TM7 subfamily. It is abundantly expressed in the in thyroid gland, brain, heart, and various tumor cells. Previous studies have suggested that GPR56 may inhibit the progression and metastasis of melanomas by interaction with extracellular-matrix proteins, such as Tissue Transglutaminase. GPR56 also plays a role in regulating VEGF production and angiogenesis via a PKCα-mediated pathway. GPR56 also plays a critical role in the development of the frontal cortex; previous studies have reported that mutations in GPR56 result in disorganized cortical lamination, which is most pronounced in the frontal cortex. This condition is known as bilateral frontoparietal polymicrogyria or BFPP.

产品信息
格式	Purified
控制	Brain tissue lysate from E13-E14 mouse
演示	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	This Anti-G-protein coupled receptor 56 (GPR56) Antibody, clone H11 is validated for use in Western Blotting, ICC, IHC for the detection of G-protein coupled receptor 56 (GPR56).
主要应用	Immunohistochemistry Western Blotting Immunocytochemistry
应用说明	Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in E14.5 mouse brain tissue. (Luo, R., et al. (2011). Proc Natl Acad Sci U S A. 108(31):12925-12930.) Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in meningeal fibroblasts (MFs). (Luo, R., et al. (2011). Proc Natl Acad Sci U S A. 108(31):12925-12930.)

生物信息
免疫原品种	N-terminal fragment of mouse GPR56
克隆	H11
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
同种型	IgG1κ
品种反应性	Mouse
Species Reactivity Note	Demonstrated to react with Mouse. Predicted to react with Human based on 100% sequence homology.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_001185823
基因符号	BFPP GPR56 TM7XN1 TM7LN4 EGF-TM7-like
纯化方法	Protein G purified
UniProt编号	Q8K209

产品使用声明
质量保证	Evaluated by Western Blot in brain tissue lysate from E13-E14 mouse. Western Blot Analysis: 0.5 μg/mL of this antibody detected G-protein coupled receptor 56 in 10 µg of brain tissue lysate from E13-E14 mouse.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABN310,Anti-G-protein coupled receptor 56 (GPR56) Antibody, clone H11

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