merck millipore,默克密理博,MABN543,Anti-Gs protein Antibody, alpha subunit, clone N192/12

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H	WB	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABN543
描述	Anti-Gs protein Antibody, alpha subunit, clone N192/12
Alternate Names	Adenylate cyclase-stimulating G alpha protein Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
背景信息	The heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) mediate signaling from a large number of G-protein coupled receptors (GPCR) to a variety of intracellular effectors. G-proteins are composed of a 36-52 kDa α-subunit, a 35-36 kDa β-subunit, and an 8-10 kDa γ-subunit. They are classified based on the nature of their α-subunit. Gs is ubiquitously expressed and couples receptors to adenylyl cyclase and promotes intracellular cAMP generation. Mutations in Gs-α can lead to constitutive activation of receptors leading to development of endocrine tumors, fibrous dysplasia of bone, and McCune-Albright syndrome. In brain tissue Gs-α activates adenyl cyclase in direct response to stimulation of several neurotransmitter receptors and facilitates depolarization-induced neurotransmitter release for synaptic transmission. Also, it is shown that Gs-stimulated adenylyl cyclase activity is significantly reduced in the Alzheimer's disease brain tissue.

产品信息
格式	Purified
控制	Rat brain membrane tissue lysate
演示	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-Gs protein Antibody, alpha subunit, clone N192/12 is a highly specific mouse monoclonal antibody & that targets Gsα & has been tested in western blotting.
主要应用	Western Blotting
应用说明	Western Blotting Analysis: 2.0 µg/mL from a representative lot detected GS protein, alpha subunit in 10 µg of SH-SY5Y cell lysate.

生物信息
免疫原品种	Recombinant protein corresponding to bovine GS protein, alpha subunit.
克隆	N192/12
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
同种型	IgG1κ
品种反应性	RatHuman
Species Reactivity Note	Demonstrated to react with Human and Rat. Predicted to react with Bovine based on immunogen design. Other homologies: Mouse (99% sequence homology).
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_851364
基因符号	GNAS1 GNAS
纯化方法	Protein G purified
UniProt编号	P04896

产品使用声明
质量保证	Evaluated by Western Blotting in rat brain membrane tissue lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected GS protein, alpha subunit in 10 µg of rat brain membrane tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABN543,Anti-Gs protein Antibody, alpha subunit, clone N192/12

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