merck millipore,默克密理愽
  • merck millipore,默克密理博,01-208,IGF-I, somatomedins, insulin-like growth factors

  • merck millipore,默克密理博,01-208,IGF-I, somatomedins, insulin-like growth factors

    产品名称：IGF-I, somatomedins, insulin-like growth factors
    产品型号：01-208
    The IGF-I protein, somatomedins, insulin-like growth factors (resistant to IGFBPs) is available in a 25 µg format.

    merck millipore,默克密理博,01-208,IGF-I, somatomedins, insulin-like growth factors

  • 产品介绍
  • merck millipore,默克密理博,01-208,IGF-I, somatomedins, insulin-like growth factors

    重要规格表

    主要应用 品种 来源
    CULTHumanRecombinant human IGF-I expressed in E. coli.
    描述
    产品目录编号 01-208
    品牌系列 Upstate
    商名
    • Upstate
    描述 IGF-I, somatomedins, insulin-like growth factors
    背景信息 Recombinant human IGF-I (Receptor Grade) expressed in E.coli. Human insulin-like growth factor-I (IGF-I) is a single chain 70 amino acid polypeptide that shares structural homology with insulin and human IGF-II. IGF-I plays a critical role in growth, differentiation and development via autocrine, paracrine and endocrine mechanisms. It is a mitogen and also has effects on cell migration and differentiation. IGF-I is a regulator of metabolism and is also implicated in the pathophysiology of cancer, diabetes and obesity.
    产品信息
    演示 Lyophilized from 0.1M acetic acid
    应用
    应用 The IGF-I protein, somatomedins, insulin-like growth factors (resistant to IGFBPs) is available in a 25 µg format.
    主要应用
    • Cell Culture
    生物信息
    来源 Recombinant human IGF-I expressed in E. coli.
    品种 Human
    Entrez基因编号
    • NM_000618.2
    Entrez基因汇总 The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972 [PubMed 4550398]). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986 [PubMed 3455760]; Rosenfeld, 2003 [PubMed 14657423]).[supplied by OMIM]
    基因符号
    • IGF-IB
    • IGF1
    • IBP1
    • IGFI
    • IGF-IA
    • MGF
    物理形式 Lyophilized
    纯化方法 Sterilized through a 0.2 micron membrane filter
    UniProt编号
    • P01343
    • P05019
    UniProt汇总 FUNCTION: SwissProt: P05019 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.| P01343 # The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
    SIZE: 195 amino acids; 21841 Da
    SUBCELLULAR LOCATION: Secreted.
    DOMAIN: SwissProt: P05019
    DISEASE: SwissProt: P05019 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.| P01343 # Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
    SIMILARITY: SwissProt: P05019 ## Belongs to the insulin family.| P01343 ## Belongs to the insulin family.
    产品使用声明
    质量保证 Routinely evaluated in in chicken embryo fibroblasts over control cultures without IGF-I
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 25 µg

    merck millipore,默克密理博,01-208,IGF-I, somatomedins, insulin-like growth factors

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