merck millipore,默克密理博,ABN486,Anti-Anosmin Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	ICC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABN486
描述	Anti-Anosmin Antibody
Alternate Names	KALIG1 Anosmin Anosmin-1 Adhesion molecule-like X-linked Kallmann syndrome protein KALIG-1 KAL1 HHA KMS ADMLX KAL
背景信息	Anosmin is a large (100 kDa) secreted peripheral membrane heparin binding glycoprotein that plays a role in neurodevelopment. Anosmin influences the patterning of the mitral and tufted cell collaterals and stimulates axon elongation and branching in the olfactory system, and it seems to have a critical role in the spatiotemporal arrangement in cranial neural cell formation. The protein interacts with FGFR1 and promotes FGF receptor mediated gene expression but it also inhibits BMP5 and WNT3A signaling activities. It is thought through this orchestration that Anosmin controls the epithelial–mesenchymal transition and the mesenchymal–epithelial transition during neural crest cell development. Mutations in the Anosmin gene, KAL1, are the cause of hypogonadotropic hypogonadism 1. A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. EMD-Millipore’s anti-Anosmin rabbit polyclonal antibody has been tested in western blot against human MCF7 cells and immunocytochemistry against MCF7 cells in culture.

产品信息
格式	Affinity Purified
控制	MCF7cell lysate
演示	Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

应用
应用	Anti-Anosmin Antibody is a highly specific rabbit polyclonal antibody, that targets Anosmin & has been tested in western blotting & ICC.
主要应用	Immunocytochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Anosmin in human cerebellum, rat cerebellum, and human thalamus tissues. Immunocytochemistry Analysis: 5 µg/mL from a representative lot detected Anosmin in MCF7 cells.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to human Anosmin.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	Human
抗体类型	Polyclonal Antibody
基因符号	KAL1
纯化方法	Antigen Affinity purified
UniProt编号	P23352

产品使用声明
质量保证	Evaluated by Western Blotting in MCF7 cell lysate. Western Blotting Analysis: 1µg/mL of this antibody detected Anosmin in 15 µg of MCF7 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,ABN486,Anti-Anosmin Antibody

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