merck millipore,默克密理博,559399,SB 203580, Sulfone - CAS 152121-46-5

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Merck Millipore 默克密理愽

merck millipore,默克密理博,559399,SB 203580, Sulfone - CAS 152121-46-5 - Calbiochem

经验配方	CAS号
C₂₁H₁₆FN₃O₂S	152121-46-5

描述
概述	A cell permeable, reversible, and ATP-competitive sulfone analog of the p38 MAP kinase inhibitor SB 203580 (Cat. No. 559389). Potently inhibits p38 kinase (IC₅₀= 30 nM) and inhibits IL-1 production in human monocytes (IC₅₀ = 200 nM).
产品目录编号	559399
品牌系列	Calbiochem®
同义词	4-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole, p38 MAP Kinase Inhibitor XII

参考
参考	Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.

生物信息
主靶	P38K
主靶IC₅₀	30 nM and 200 nM against p38 kinase and IL-1 production, respectively, in human monocytes.
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,559399,SB 203580, Sulfone - CAS 152121-46-5 - Calbiochem

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