merck millipore,默克密理愽
  • merck millipore,默克密理博,MABN43,Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4

  • merck millipore,默克密理博,MABN43,Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4

    产品名称：Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4
    产品型号：MABN43
    This Anti--Apolipoprotein E4 antibody is validated for use in IP, WB, IH for the detection of ApoE4.

    merck millipore,默克密理博,MABN43,Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4

  • 产品介绍
  • merck millipore,默克密理博,MABN43,Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABN43
    描述 Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4
    Alternate Names
    • Apolipoprotein E4
    • Apolipoprotein E
    • Apo-E
    • ApoE4
    背景信息 Apolipoprotein is a polymorphic plasma protein that exists as three isoforms: ApoE4, ApoE3, and ApoE2, which differ in the combination of cysteine and arginine residues located at position 122 and 158. The 35 kDa ApoE4 isoform contains arginine at both locations, and is produced in the liver and brain, although it is widely expressed in other tissues, such as the lung, spleen, and ovary. Like other isoforms, ApoE4 is a ligand for low density lipoprotein receptors (LDL) and plays a critical role in the transport and metabolism of lipids. In addition to its role in maintaining cardiovascular function, ApoE4 is also critically involved in neuronal plasticity, synaptogenesis, aging, and neurodegenerative disorders. Mice deficient in ApoE4 show age-dependent abnormalities in synaptic structure and impaired long term potentiation. Additionally, ApoE4 has a well-documented role in the pathology of Alzheimer’s disease.
    产品信息
    格式 Purified
    控制
    • Recombinant Apolipoprotein E protein
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti--Apolipoprotein E4 antibody is validated for use in IP, WB, IH for the detection of ApoE4.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:2,000-4,000 dilution from a representative lot detected ApoE4 in human Alzheimer's diseased brain and human cerebellum tissues.

    Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to detect ApoE4 in CHO cells secreting ApoE4. (Image courtesy of Dr. Egon Ogris, Medical University of Vienna)
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human ApoE4.
    克隆 4E4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes ApoE4 but not ApoE3 or ApoE2.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000032
    基因符号
    • APOE
    纯化方法 Protein G purified
    UniProt编号
    • P02649
    产品使用声明
    质量保证 Evaluated by Western Blot in recombinant ApoE4 protein.

    Western Blot Analysis: A 1:100,000 dilution detected ApoE4 in 10 µg of recombinant ApoE4 protein.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABN43,Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4

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