merck millipore,默克密理愽
  • merck millipore,默克密理博,07-662,Anti-Estrogen-related Receptor α Antibody

  • merck millipore,默克密理博,07-662,Anti-Estrogen-related Receptor α Antibody

    产品名称：Anti-Estrogen-related Receptor α Antibody
    产品型号：07-662
    Anti-Estrogen-related Receptor α Antibody is a Rabbit Polyclonal Antibody for detection of Estrogen-related Receptor α also known as ERR alpha & has been tested in EMSA, IHC, IP & WB.

    merck millipore,默克密理博,07-662,Anti-Estrogen-related Receptor α Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-662,Anti-Estrogen-related Receptor α Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, Ht, MWB, EMSA, IHCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-662
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Estrogen-related Receptor α Antibody
    概述 Estrogen-related receptor alpha is a nuclear receptor protein related to the Estrogen receptor. It is reported to interact with estrogen and similar steroids and functions as a transcriptional activator.
    背景信息 This protein is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. In mouse, ERR alpha is expressed in many adult and embryonic tissues (particularly at the onset of ossification) as well as in several osteoblast cell lines. ERR alpha expression has been documented in mouse in brain, spinal cord, pituitary gland and heart.
    产品信息
    格式 Purified
    控制
    • Positive Control Included: HeLa Nuclear Extract (12-309).
    演示 Protein A Purified rabbit IgG in a solution of 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.135M NaCl, and 0.035% sodium azide as a preservative.
    应用
    应用 Anti-Estrogen-related Receptor α Antibody is a Rabbit Polyclonal Antibody for detection of Estrogen-related Receptor α also known as ERR alpha & has been tested in EMSA, IHC, IP & WB.
    主要应用
    • Western Blotting
    • Electrophoretic Mobility Shift Assay
    • Immunohistochemistry
    生物信息
    免疫原品种 Ovalbumin-conjugated, synthetic peptide corresponding to amino acids 339-364 of human Estrogen Receptor-Related α
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Estrogen-related Receptor α.
    同种型 IgG
    品种反应性 RatHumanHamsterMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000125.2
    Entrez基因汇总 This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
    基因符号
    • DKFZp686N23123
    • ESR1
    • ER-alpha
    • ESR
    • Era
    • ER
    • NR3A1
    • ESRA
    纯化方法 Protein A purfied
    UniProt编号
    • P03372
    UniProt汇总 FUNCTION: SwissProt: P03372 # Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
    SIZE: 595 amino acids; 66216 Da
    SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with JARID1A. Interacts with SMARD1. Interacts with SLC30A9 (By similarity). Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1.
    SUBCELLULAR LOCATION: Nucleus.
    DOMAIN: SwissProt: P03372 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
    PTM: Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
    SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
    MISCELLANEOUS: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone- receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot on RIPA lysates from HeLa nuclear extracts.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-662,Anti-Estrogen-related Receptor α Antibody

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