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merck millipore,默克密理博,239807,InSolution™ Cyclopamine-KAAD - Calbiochem
产品名称：InSolution™ Cyclopamine-KAAD - Calbiochem
产品型号：239807
A cell-permeable potent analog of Cyclopamine that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity.
merck millipore,默克密理博,239807,InSolution™ Cyclopamine-KAAD - Calbiochem
- 产品介绍
重要规格表
经验配方 C₄₄H₆₃Nl₃O₄ 描述 概述 A cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. The solid form of this compound (Cat. No. 239804) is also available. 产品目录编号 239807 品牌系列 Calbiochem®
同义词 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine 参考 参考 Siegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
Watkins, D.N., et al. 2003. Nature 422, 313.
Berman, D.M., et al. 2002. Science 297, 1559.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Chen, J.K., et al. 2002. Genes Dev. 16, 2743.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
Taipale, J., et al. 2000. Nature 406, 1005.产品信息 形式 Liquid 配方 A 1 mM (50 µg/72 µL) solution of Cyclopamine-KAAD (Cat. No. 239804) in DMSO. Hill配方 C₄₄H₆₃Nl₃O₄ Molar Mass 698 吸湿 Hygroscopic
结构配方图像 生物信息 主靶 SmoA1 纯度 ≥70% by HPLC (sum of two isomers) 理化信息 细胞可渗透 Y 安全信息 R相 R: 36/38
Irritating to eyes and skin.S相 S: 26-36/37/39
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.储存和货运信息 货运代码 Dry Ice Only
毒性 Irritant
储存 ≤ -70°C
避光 Protect from light
吸湿 Hygroscopic
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. 包装信息 惰性气体下包装 Packaged under inert gas
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