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- 体外诊断/OEM材料和试剂
- 产品介绍
描述 产品目录编号 MAB1312-K 品牌系列 Chemicon®
商名 - Chemicon
描述 Mouse anti-Human IgG4, clone HP6023, Fc (1mg) 概述 This product is intended for use by IVD manufacturers. 产品信息 格式 Purified 演示 Purified immunoglobulin. 0.02MPB+ 0.25M NaCl , Ph=7.6, 0.1% soduim azide. 应用 主要应用 - Western Blotting
- ELISA
应用说明 This antibody employed as both a capture antibody and a detection antibody for human IgG subclass 4 in enzyme linked immunosorbent assays, radio-immunoassay and EIA affinity immunoblots (Papadea et al., 1985; Hamilton, et al., 1987).
Final working dilutions must be determined by end user.生物信息 表位 Fc fragment 克隆 HP6023 浓缩 1mg/mL 宿主 Mouse 特异性 Human IgG4 Fc. ELISA Specificity: (Hamilton et al., 1987) human IgG subclass 1- 0.08% human IgG subclass 2 - 0.01% human IgG subclass 3 - 0.04% human IgG subclass 4-100% Isoelectric Focusing: mean pI 7.7 同种型 IgG3 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004001.3
- NM_001002273.1
- NM_001002274.1
- NM_001002275.1
基因符号 - FCGR2
- FCGR2B
- CDw32
- CD32B
- IGFR2
- CD32
- Fc-gamma-RIIb
- FCG2
- FcRII-b
UniProt编号 - P31994
UniProt汇总 FUNCTION: SwissProt: P31994 # Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
SIZE: 310 amino acids; 34044 Da
SUBUNIT: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
DOMAIN: SwissProt: P31994 Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.DISEASE:SwissProt: P31994 # A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.
SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2 -8°C for up to one year in undiluted aliquots. 包装信息 数量 Bulk packaging. Please inquire.
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