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merck millipore,默克密理博,MABN38,Anti-Neuroligin-1 Antibody, clone N97A/31
产品名称：Anti-Neuroligin-1 Antibody, clone N97A/31
产品型号：MABN38
Detect Neuroligin-1 using this Anti-Neuroligin-1 Antibody, clone N97A/31 validated for use in IH & WB.
merck millipore,默克密理博,MABN38,Anti-Neuroligin-1 Antibody, clone N97A/31
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MABN38 描述 Anti-Neuroligin-1 Antibody, clone N97A/31 Alternate Names - neuroligin-1, NLGN1
- neuroligin 1
背景信息 Neuroligin-1 is a neuronal cell surface protein belonging to the type-B carboxylesterase/lipase family. It is a necessary component in the maturation of excitatory synapses for their normal, functional development, and is necessary to the regulation of synaptic plasticity and the development of long-term memory within the adult amygdala in mammals. It is believed to participate in cell-cell-interaction through the assembly of intracellular junction by the binding of beta-neurexins, and may also be a factor in the maintenance and assembly of synaptic junctions. It is also thought to have involvement in excitatory synaptic specification. Within brain tissue, Neuroligin-1 is primarily observed in neurons and spinal cord. 产品信息 格式 Purified 控制 - Rat brain membrane tissue lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Neuroligin-1 using this Anti-Neuroligin-1 Antibody, clone N97A/31 validated for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry Analysis: 1:300 dilution of this antibody from a previous lot detected Neuroligin-1 in rat adult brain tissue. 生物信息 免疫原品种 Recombinant protein corresponding to rat Neuroligin-1. 克隆 N97A/31 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 Rat Species Reactivity Note Demonstrated to react with rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_446320
Entrez基因汇总 transmembrane ligand for neurexins; involved in development and maturation of synaptic connections [RGD]. 基因符号 - NL1
- NLGN1
纯化方法 Protein G UniProt编号 - Q62765
UniProt汇总 FUNCTION: Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. Seems to play role in formation or maintenance of synaptic junctions. In vitro, triggers the de novo formation of presynaptic structures (By similarity). May be involved in specification of excitatory synapses.
SUBUNIT STRUCTURE: Interacts with neurexin 1-beta isoform 3/Beta 4B5A and isoform 4/Beta 4B5B. Interacts with neurexin 2-beta isoform 3/Beta 4B5A, isoform 4/Beta 4B5B, isoform 7/Beta 4B5A6 and issoform 8/Beta 4B5B6. Interacts with corresponding neurexin 3-beta isoforms. Interacts through its C-terminus with DLG4/PSD-95 third PDZ domain (By similarity). Interacts with AIP1 and PDZRN3.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell junction › synapse. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Note: Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and NMDAR1/glutamate [NMDA] receptor subunit zeta 1.
TISSUE SPECIFICTY: Expressed in brain, almost exclusively in neurons, and spinal chord.
DEVELOPMENTAL STAGE: Expression is low in embryonic brains (E12-E16) but increases dramatically after birth (postnatal days P0-P3) and reaches a plateau during the period when most synapses are formed (P5-P8).
PTM: The N-terminus is blocked.
SEQUENCE SIMILARITIES: Belongs to the type-B carboxylesterase/lipase family.产品使用声明 质量保证 Evaluated by Western Blot in rat brain membrane tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Neuroligin-1 on 10 µg of rat brain membrane tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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