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品种反应性 主要应用 宿主 格式 抗体类型 Sh, H, M, R ICC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-138 品牌系列 Upstate
商名 - Upstate
描述 Anti-Cyclin A Antibody 背景信息 The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Cyclin A is a member of the Cyclin A family that can bind and activate Cdc2 and Cdk2 and is involved in the control of mitosis and S phase. During S phase, cyclin A forms a complex with Cdk2, the pRB-related protein p107 and E2F. 产品信息 格式 Purified 控制 - Daudi cells
演示 Lyophilized 应用 应用 Detect Cyclin A with Anti-Cyclin A Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 peptide corresponding amino acid residues 417-432 (C-KHGVSLLNPPETL-N-L) 宿主 Rabbit 特异性 p58cyclin A; does not cross-react with cyclin B or cyclin D2, or 3 同种型 IgG 品种反应性 SheepHumanMouseRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001237
Entrez基因汇总 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. 基因符号 - CCNA
- CCNA2
- Cyclin-A2
- CCN1
- Cyclin-A
纯化方法 Protein G chromatography UniProt编号 - P20248
UniProt汇总 FUNCTION: SwissProt: P20248 # Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
SIZE: 432 amino acids; 48537 Da
SUBUNIT: Interacts with the CDK2 and CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly destroyed at mitosis.
SIMILARITY: SwissProt: P20248 ## Belongs to the cyclin family. Cyclin AB subfamily.产品使用声明 质量保证 routinely evaluated by immunoblot on HeLa nuclear extract 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,371709,GPR109b Agonist - CAS 306935-41-1 - Calbiochem
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