merck millipore,默克密理博,MABN1090,Anti-Thioredoxin 1 Antibody, clone EPR6110, rabbit monoclonal

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merck millipore,默克密理博,MABN1090,Anti-Thioredoxin 1 Antibody, clone EPR6110, rabbit monoclonal
产品名称：Anti-Thioredoxin 1 Antibody, clone EPR6110, rabbit monoclonal
产品型号：MABN1090
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.

merck millipore,默克密理博,MABN1090,Anti-Thioredoxin 1 Antibody, clone EPR6110, rabbit monoclonal

产品介绍

merck millipore,默克密理博,MABN1090,Anti-Thioredoxin 1 Antibody, clone EPR6110, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABN1090
描述	Anti-Thioredoxin 1 Antibody, clone EPR6110, rabbit monoclonal
Alternate Names	Thioredoxin 1 Thioredoxin Trx ATL-derived factor ADF Surface-associated sulphydryl protein SASP
背景信息	Thioredoxin (TRX), ATL-derived factor (ADF), surface-associated sulphydryl protein (SASP) are all names for Thioredoxin 1 protein, a small class of enzyme-like redox proteins. Thioredoxin 1 is encoded by the TXN/TRDX, TRX, TRX1 gene. Redox proteins like Thioredoxin 1 are found in all organisms and their function is to facilitate oxidation and reduction of protein disulfide bonds by thiol-disulfide exchange and thus mediate cellular redox balance, and ultimately in many cases, cell fate. Impaired cellular redox balance has been linked with age-related diseases, and neurodegenerative diseases, such as Alzheimer and Parkinson's disease. Thioredoxin 1 contains two cysteine amino acid residues in a vicinal arrangement (i.e., next to each other), which allows it to form an internal disulfide bond, or disulfide bonds with other proteins. As such, it can be used as a repository of reduced or oxidized disulfide bond moieties. As its name would imply, Thioredoxin 1 functions to reduce oxidative stress within cells and thus promotes better health. Interestingly mice that over express Thioredoxin 1 appear to live much longer and are more resistant to inflammation than non-over expressing mice suggesting that thioredoxin’s efforts in reducing the number of free radicals and other oxidizing agents within cells leads to longevity. Thioredoxin 1 plays a role in nitric oxide metabolism, and can act as an active inhibitor of caspase 3 by nitrosylating caspase 3’s active site in response to NO activation. Thioredoxin also induces AP-1 protein and FOS/JUN gene expression after ionizing radiation, thereby providing a mechanism aimed at cell survival. Finally, going beyond its protective and survival roles, Thioredoxin 1 and its brother redox proteins are involved in various other cellular processes, such as cell-cell communication, signal transduction, and DNA synthesis.

产品信息
格式	Unpurified
控制	MCF-7, THP-1, HeLa, and HepG2 cell lysates
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:250-500 dilution from a representative lot detected Thioredoxin 1 in human colon tissue. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic peptide corresponding to human Thioredoxin 1.
克隆	EPR6110
宿主	Rabbit
品种反应性	Human
抗体类型	Monoclonal Antibody
基因符号	TRX1 TXN TRDX TRX
纯化方法	Unpurified
UniProt编号	P10599

产品使用声明
质量保证	Evaluated by Western Blotting in MCF-7, THP-1, HeLa, and HepG2 cell lysates. Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected MCF-7, THP-1, HeLa, and HepG2 cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.