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merck millipore,默克密理博,260962,DNA-PK Inhibitor III - CAS 404009-40-1 - Calbiochem
产品名称：DNA-PK Inhibitor III - CAS 404009-40-1 - Calbiochem
产品型号：260962
The DNA-PK Inhibitor III, also referenced under CAS 404009-40-1, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation app More>>
merck millipore,默克密理博,260962,DNA-PK Inhibitor III - CAS 404009-40-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₂H₁₅NO₃ 404009-40-1 描述 概述 A cell-permeable aryl-morpholino compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 120 nM) and PI 3-Kinase catalytic subunit p110β (IC50 = 135 nM). It inhibits DNA-PK-mediated cellular DNA DSB (double strand break) repair (EC50 = 68 µM) and enhances DSB-induced antitumor activity both in vitro and in vivo, while exhibiting no cytotoxic effects (up to 50 µM) in the absence of DSBs. It inhibits PI 3-K p110α, p110γ, and p110δ only at much higher concentrations (IC50 = 1.4, 0.88, and 1.0 µM, respectively) and exhibits no effect against a panel of several other kinases, including, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12, even at concentrations as high as 100 µM. 产品目录编号 260962 品牌系列 Calbiochem®
同义词 IC86621, 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone 参考 参考 Kashishian, A., et al. 2004. Mol. Cancer Ther. 2, 1257.
Willmore, E., et al. 2004. Blood,103, 4659.产品信息 CAS号 404009-40-1 具有ATP竞争性 Y 形式 Off-white solid Hill配方 C₁₂H₁₅NO₃ 化学配方 C₁₂H₁₅NO₃ Molar Mass 221.3 可逆 Y 结构配方图像 生物信息 主靶 DNA-PK 主靶IC50 120 nM against DNA-PK 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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