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merck millipore,默克密理博,06-1297,Anti-U1-70K Antibody
产品名称：Anti-U1-70K Antibody
产品型号：06-1297
Anti-U1-70K Antibody is a Rabbit Polyclonal Antibody for detection of U1-70K also known as small nuclear ribonucleoprotein 70kDa (U1) & has been validated in WB, ICC.
merck millipore,默克密理博,06-1297,Anti-U1-70K Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-1297 描述 Anti-U1-70K Antibody Alternate Names - U1 snRNP 70 kDa
- small nuclear ribonucleoprotein 70kDa (U1)
- U1 small nuclear ribonucleoprotein 70 kDa
- small nuclear ribonucleoprotein 70kDa (RNP antigen)
背景信息 U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) is one of three specific proteins found within the U1 snRNP core, which includes at least seven core proteins found in all U snRNPs and three specific proteins; U1-70K, U1-A, and U1-C. U1-70K is involved in mediating pre-mRNA splicing through binding the loop I region of U1-snRNA with its RPM (RNA recognition motif) binding domain. In addition, its RNA binding domain, U1-70K also contains two argine-rich regions, accented with acidic or serine residues, that is thought to have trans-acting functions. Alternative splicing results in 4 known isoforms. Truncated forms of U1-70K are unable to bind RNA. 产品信息 格式 Purified 控制 - HepG2 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-U1-70K Antibody is a Rabbit Polyclonal Antibody for detection of U1-70K also known as small nuclear ribonucleoprotein 70kDa (U1) & has been validated in WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 1:500 of a representative lot of this antibody has been shown to detect U1-70K in NIH/3T3, A431, and HeLa cells. 生物信息 免疫原品种 Recombinant protein corresponding to C-terminal domain of human U1-70K. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes U1-70K. 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with human and mouse.
抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003080.2
基因符号 - U1AP
- U1RNP
- U1-70K
- U170K
- RNPU1Z
- SNRP70
- U1AP1
- RPU1
- snRNP70
- SNRNP70
纯化方法 Protein A purfied UniProt编号 - P08621
UniProt汇总 FUNCTION: Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
SUBUNIT STRUCTURE: Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Interacts with dephosphorylated SFRS13A and SFPQ. Interacts with NUDT21/CPSF5, CPSF6, SFRS2IP, and ZRANB2.
SUBCELLULAR LOCATION: Nucleus.
PTM: The N-terminus is blocked.
Extensively phosphorylated on serine residues in the C-terminal region.
MISCELLANEOUS: Major ribonucleoprotein antigen recognized by the sera from patients with autoimmune diseases, such as systemic lupus erythematosus.
SEQUENCE SIMILARITIES: Contains 1 RRM (RNA recognition motif) domain.
SEQUENCE CAUTION: The sequence CAA28352.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA29964.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA29966.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Western Blot in HepG2 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected U1-70K on 10 µg of HepG2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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