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merck millipore,默克密理博,MABF63,Anti-Activation-induced cytidine deaminase (AID) Antibody, clone 328.8
产品名称：Anti-Activation-induced cytidine deaminase (AID) Antibody, clone 328.8
产品型号：MABF63
Anti-Activation-induced cytidine deaminase (AID) Antibody, clone 328.8 detects level of Activation-induced cytidine deaminase (AID) & has been published & validated for use in WB, IH.
merck millipore,默克密理博,MABF63,Anti-Activation-induced cytidine deaminase (AID) Antibody, clone 328.8
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H IHC, WB R Purified Monoclonal Antibody 描述 产品目录编号 MABF63 描述 Anti-Activation-induced cytidine deaminase (AID) Antibody, clone 328.8 Alternate Names - Cytidine aminohydrolase
- activation-induced cytidine deaminase
- integrated into Burkitt's lymphoma cell line Ramos
背景信息 Activation-induced cytidine deaminase (AID) is a 24 kDa, RNA-editing protein that is necessary for the initiation of both somatic hypermutation (SHM) and class switch recombination (CSR) of the Ig gene through the production of U:G mismatches in DNA, and is primarily found in activated B cells. AID expression has also been observed in several varying types of B cell lymphomas such as; Burkitt’s lymphoma, Hodgkin’s lymphoma, hairy cell lymphoma, follicular lymphoma, mantle cell lymphoma, mucosa-associated lymphoid tissue lymphoma, and mediastinal B cell lymphoma. Mutations in AID expression are causal to autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2), which is characterized by serum containing IgM but lacking IgG, IgA and IgE, which leads to severe susceptibility to bacterial infections. 产品信息 格式 Purified 控制 - Raji cell lysate
演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Activation-induced cytidine deaminase (AID) Antibody, clone 328.8 detects level of Activation-induced cytidine deaminase (AID) & has been published & validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Activation-induced cytidine deaminase (AID). 克隆 328.8 宿主 Rat 同种型 IgG2aκ 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_065712
Entrez基因汇总 This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq]. 基因符号 - CDA2
- AID
- ARP2
- HIGM2
纯化方法 Protein G Purified UniProt编号 - Q9GZX7
UniProt汇总 FUNCTION: RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.
CATALYTIC ACTIVITY: Cytidine + H2O = uridine + NH3.
COFACTOR: Zinc (By similarity).
TISSUE SPECIFICTY: Strongly expressed in lymph nodes and tonsils.
INVOLVEMENT IN DISEASE: Defects in AICDA are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]. HIGM2 is characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.
SEQUENCE SIMILARITIES: Belongs to the cytidine and deoxycytidylate deaminase family.产品使用声明 质量保证 Evaluated by Western Blot in Raji cell lysate.
Western Blot Analysis: 1:2,000 dilution of this antibody detected Activation-induced cytidine deaminase (AID) on 10 µg of Raji cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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