merck millipore,默克密理愽
  • merck millipore,默克密理博,489476,LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem

  • merck millipore,默克密理博,489476,LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem

    产品名称：LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem
    产品型号：489476
    The LSD1 Inhibitor, also referenced under CAS 927019-63-4, controls the biological activity of LSD1. This small molecule/inhibitor is primarily used for Cell Signaling applications.

    merck millipore,默克密理博,489476,LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,489476,LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₄₀Cl₄N₈927019-63-4
    描述
    概述 A bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 µM in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 µM to 10 µM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.
    产品目录编号 489476
    品牌系列 Calbiochem®
    同义词 LSD Inhibitor I, BHC110 Inhibitor I, Histone Lysine Demethylase Inhibitor III, KDM1 Inhibitor I
    参考
    参考 Sharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
    Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
    Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.
    产品信息
    CAS号 927019-63-4
    形式 Pale yellow to yellow solid
    Hill配方 C₁₅H₄₀Cl₄N₈
    化学配方 C₁₅H₄₀Cl₄N₈
    Molar Mass 474.34
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 H₂O
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,489476,LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,SCME001,EndoGRO-LS Complete Culture Media Kit
下一件merck millipore产品：merck millipore,默克密理博,480001,NDSB-195 - CAS 160255-06-1 - Calbiochem


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