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  • merck millipore,默克密理博,46-655MAG,MILLIPLEX MAP Phospho STAT1 (Tyr701) Magnetic Bead MAPmate - Cell Signaling Single Plex Assay

  • merck millipore,默克密理博,46-655MAG,MILLIPLEX MAP Phospho STAT1 (Tyr701) Magnetic Bead MAPmate - Cell Signaling Single Plex Assay

    产品名称：MILLIPLEX MAP Phospho STAT1 (Tyr701) Magnetic Bead MAPmate - Cell Signaling Single Plex Assay
    产品型号：46-655MAG
    This MILLIPLEX MAP Phospho STAT1 (Tyr701) Magnetic Bead MAPmate is a Cell Signaling Single Plex Assay. The analyte available for this kit is STAT1 (Tyr701).

    merck millipore,默克密理博,46-655MAG,MILLIPLEX MAP Phospho STAT1 (Tyr701) Magnetic Bead MAPmate - Cell Signaling Single Plex Assay

  • 产品介绍
  • merck millipore,默克密理博,46-655MAG,MILLIPLEX MAP Phospho STAT1 (Tyr701) Magnetic Bead MAPmate - Cell Signaling Single Plex Assay

    重要规格表

    可用的分析物 品种反应性 主要应用 检测方法
    STAT1 (Tyr701)M, HMplexLuminex xMAP
    描述
    产品目录编号 46-655MAG
    商名
    • MILLIPLEX
    描述 MILLIPLEX MAP Phospho STAT1 (Tyr701) Magnetic Bead MAPmate - Cell Signaling Single Plex Assay
    产品信息
    检测方法 Luminex xMAP
    配置 Single Plex
    板面类型 Cell Signaling
    应用
    应用 This MILLIPLEX MAP Phospho STAT1 (Tyr701) Magnetic Bead MAPmate is a Cell Signaling Single Plex Assay. The analyte available for this kit is STAT1 (Tyr701).
    主要应用
    • Multiplexing
    应用说明 • An overnight (4°C) incubation is recommended for best results
    • This assay requires 25 µL diluted cell lysate per well
    • Please consult the buffer compatibility chart or protocol for appropriate buffer choice
    • 1 - 25 μg cell lysate/well (recommended starting concentration is 20 μg)
    生物信息
    品种反应性 MouseHuman
    可用的分析物
    • STAT1 (Tyr701)
    Entrez基因编号
    • NM_003152
    Entrez基因汇总 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
    修改
    • Phosphorylation
    UniProt编号
    • P42224
    UniProt汇总 Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Recommended storage for kit components is 2 - 8°C
    包装信息
    数量 96-well plate
    包装 96-well Plate

    merck millipore,默克密理博,46-655MAG,MILLIPLEX MAP Phospho STAT1 (Tyr701) Magnetic Bead MAPmate - Cell Signaling Single Plex Assay

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