merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE89,Anti-Brm Antibody, clone 1H7A10

  • merck millipore,默克密理博,MABE89,Anti-Brm Antibody, clone 1H7A10

    产品名称：Anti-Brm Antibody, clone 1H7A10
    产品型号：MABE89
    Use Anti-Brm Antibody, clone 1H7A10 (Rat Monoclonal Antibody) validated in WB, IHC to detect Brm also known as ATP-dependent helicase SMARCA2 or SNF2/SWI2-like protein 2.

    merck millipore,默克密理博,MABE89,Anti-Brm Antibody, clone 1H7A10

  • 产品介绍
  • merck millipore,默克密理博,MABE89,Anti-Brm Antibody, clone 1H7A10

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MIHC, WBRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE89
    描述 Anti-Brm Antibody, clone 1H7A10
    Alternate Names
    • BRG1-associated factor 190B
    • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
    • ATP-dependent helicase SMARCA2
    • probable global transcription activator SNF2L2
    • sucrose nonfermenting 2-like protein 2
    • SNF2/SWI2-like protein 2
    • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2
    • global transcription activator homologous sequence
    • Protein brahma homolog
    • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
    背景信息 BAF190B (BRG1-associated factor 190B), also known as protein brahma homolog (Brm), and SNF2-alpha, functions as a transcriptional coactivator. This protein contains a helicase domain and is a member of the SWI/SNF family of proteins and is part of the SWI-SNF chromatin remodeling complex. The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. This large complex contains multiple proteins. BAF190 (Brm) and Brg-1 (SNF2-beta) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, or SNF5), BAF155 (SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).
    产品信息
    格式 Purified
    控制
    • K562 nuclear extract
    演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-Brm Antibody, clone 1H7A10 (Rat Monoclonal Antibody) validated in WB, IHC to detect Brm also known as ATP-dependent helicase SMARCA2 or SNF2/SWI2-like protein 2.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunocytochemistry:
    A representative lot of this antibody was reported to work in IC using C2C12 cells (Yasuyuki Ohkawa, SSP Stem Cell Unit, Faculty of Medicine, Kyushu University, Fukuoka, Japan.)

    Immunohistochemistry:
    A representative lot of this antibody was reported to work in IHC using mouse embryonic and postnatal brain (Yasuyuki Ohkawa, SSP Stem Cell Unit, Faculty of Medicine, Kyushu University, Fukuoka, Japan.)
    生物信息
    免疫原品种 Recombinant protein corresponding to amino acids 48-214 of mouse Brm.
    克隆 1H7A10
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    特异性 Recognizes BAF190B also known as Brm
    同种型 IgG2aκ
    品种反应性 Mouse
    Species Reactivity Note Demonstrated to react with human and mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_035546
    基因符号
    • SNF2-alpha
    • BAF190B
    • BRM
    • hBRM
    • SMARCA2
    • SNF2L2
    • Sth1p
    • SWI2
    • SNF2
    • SNF2-like 2
    • BAF190
    • SNF2LA
    • hSNF2a
    • SNF2A
    纯化方法 Protein G
    UniProt编号
    • Q6DIC0
    UniProt汇总 FUNCTION: Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Ref.2

    SUBUNIT STRUCTURE: Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Binds TOPBP1 (By similarity). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Interacts with PHF10/BAF45A. Ref.2

    SUBCELLULAR LOCATION: Nucleus (By similarity).

    PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).

    SEQUENCE SIMILARITIES: Belongs to the SNF2/RAD54 helicase family.

    Contains 1 bromo domain.

    Contains 1 helicase ATP-binding domain.

    Contains 1 helicase C-terminal domain.

    Contains 1 HSA domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in K562 nuclear extract.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected Brm on 10 µg of K562 nuclear extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE89,Anti-Brm Antibody, clone 1H7A10

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下一件merck millipore产品：merck millipore,默克密理博,573113,Sucrose, Molecular Biology Grade - CAS 57-50-1 - Calbiochem


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