merck millipore,默克密理愽
  • merck millipore,默克密理博,14-663,CaM Kinase I Protein, active, 10 µg

  • merck millipore,默克密理博,14-663,CaM Kinase I Protein, active, 10 µg

    产品名称：CaM Kinase I Protein, active, 10 µg
    产品型号：14-663
    Active, N-terminal GST-tagged, recombinant, human CaMK1, amino acids 2-end. For use in Kinase Assays.

    merck millipore,默克密理博,14-663,CaM Kinase I Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-663,CaM Kinase I Protein, active, 10 µg

    描述
    产品目录编号 14-663
    品牌系列 Upstate
    商名
    • Upstate
    描述 CaM Kinase I Protein, active, 10 µg
    概述 N-terminal GST-tagged, recombinant, human CaMK1, amino acids 2-end.
    产品信息
    演示 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 50% glycerol, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.
    应用
    应用 Active, N-terminal GST-tagged, recombinant, human CaMK1, amino acids 2-end. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed in E. coli cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_003656.3
    Entrez基因汇总 Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.
    基因符号
    • CAMK1-PEN
    • CAMKI
    • CaM-KI
    • CaMKI
    • MGC120317
    • CAMK1
    • CaMKI-alpha
    • MGC120318
    蛋白靶 CaMKI
    纯化方法 Glutathione-agarose
    靶子系列 CAMK
    UniProt编号
    • Q14012
    UniProt汇总 FUNCTION: SwissProt: Q14012 # Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes like transcriptional regulation, hormone production, translational regulation, regulation of actin filament organization and neurite outgrowth. Involved in calcium- dependent activation of the ERK pathway (By similarity). Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]- x(3)-[MVLIF]. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CTFR, MYL9, SYN1/synapsin I and SYNII/synapsin II (By similarity).
    SIZE: 370 amino acids; 41337 Da
    SUBUNIT: Monomer. Interacts with XPO1 (By similarity).
    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By similarity).
    TISSUE SPECIFICITY: Ubiquitous.
    DOMAIN:SwissProt: Q14012 The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity).
    SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of ZIPtide (#12-545).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -20°C
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-663,CaM Kinase I Protein, active, 10 µg

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