merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1964,Anti-N-WASP Antibody, phospho-specific [Ser484/Ser485]

  • merck millipore,默克密理博,AB1964,Anti-N-WASP Antibody, phospho-specific [Ser484/Ser485]

    产品名称：Anti-N-WASP Antibody, phospho-specific [Ser484/Ser485]
    产品型号：AB1964
    Detect N-WASP using this Anti-N-WASP Antibody, phospho-specific [Ser484/Ser485] validated for use in ELISA & WB.

    merck millipore,默克密理博,AB1964,Anti-N-WASP Antibody, phospho-specific [Ser484/Ser485]

  • 产品介绍
  • merck millipore,默克密理博,AB1964,Anti-N-WASP Antibody, phospho-specific [Ser484/Ser485]

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWB, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB1964
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-N-WASP Antibody, phospho-specific [Ser484/Ser485]
    Alternate Names
    • Neural Wiskott-Aldrich Syndrome Protein
    背景信息 Members of the Wiskott-Aldrich sydrome protein (WASP) family regulate the formation of actin-based cell structures in many cell types. These proteins contain C-terminal actin-binding domains that can stimulate actin polymerization. In addition, these proteins bind the ARP2/3 complex, which can nucleate actin polymerization at sites that lead to branched actin structures. WASP is expressed primarily in hematopoietic cells, while its homolog N-WASP is widely expressed. These proteins have 48% identity in human with the highest homology in the functional regions of these proteins. Phosphorylation regulates the activity of both proteins. Dual phosphorylation of WASP on serine 483 and 484 by casein kinases increase the affinity for the ARP2/3 complex. Thus, dual serine phosphorylation may be important for formation of actin-based structures in various cell types.
    产品信息
    格式 Affinity Purified
    演示 This antibody was cross-adsorbed to unphosphorylated-N-WASP (S484/S485) peptide (without carrier) then affinity purified using phospho-N-WASP (S484/S485) peptide (without carrier). Antibody is supplied in 100 μl phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
    应用
    应用 Detect N-WASP using this Anti-N-WASP Antibody, phospho-specific [Ser484/Ser485] validated for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1:1000 ELISA: 1:2000
    生物信息
    免疫原品种 Phospho-N-WASP (S484/S485) synthetic peptide (coupled to KLH) corresponding to amino acid residues around serine 484 and 485 of human N-WASP. The human WASP sequence has a similar peptide sequence surrounding serine 483 and 484.
    表位 phosphoserine484/phosphserine485
    宿主 Rabbit
    特异性 The antibody detects a 63 kDa protein corresponding to the molecular weight of phosphorylated WASP on SDS-PAGE immunoblots of Jurkat cell lysate. In rat brain, A431, human endothelial and SKN-SH cells, this antibody detects a 65 kDa protein corresponding to phosphorylated N-WASP.
    同种型 IgG
    品种反应性 RatHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003941.2
    Entrez基因汇总 The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
    基因符号
    • NWASP
    • WASL
    • DKFZp779G0847
    • MGC48327
    • N-WASP
    修改
    • Phosphorylation
    UniProt编号
    • O00401
    UniProt汇总 FUNCTION: SwissProt: O00401 # Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.
    SIZE: 505 amino acids; 54827 Da
    SUBUNIT: Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with the WW domains of PRPF40A/FBP11 (By similarity). Interacts with NOSTRIN. Interacts with Shigella flexneri protein icsA. The interaction with icsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly.
    SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity).
    SIMILARITY: SwissProt: O00401 ## Contains 1 CRIB domain. & Contains 1 WH1 domain. & Contains 2 WH2 domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 20°C for up to one year from date of receipt. Do not aliquot.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB1964,Anti-N-WASP Antibody, phospho-specific [Ser484/Ser485]

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