merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE69,Anti-Emerin Antibody, clone 7D9

  • merck millipore,默克密理博,MABE69,Anti-Emerin Antibody, clone 7D9

    产品名称：Anti-Emerin Antibody, clone 7D9
    产品型号：MABE69
    Use Anti-Emerin Antibody, clone 7D9 (Mouse Monoclonal Antibody) validated in WB, ICC to detect Emerin also known as Emery-Dreifuss muscular dystrophy, LEM domain containing 5.

    merck millipore,默克密理博,MABE69,Anti-Emerin Antibody, clone 7D9

  • 产品介绍
  • merck millipore,默克密理博,MABE69,Anti-Emerin Antibody, clone 7D9

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE69
    描述 Anti-Emerin Antibody, clone 7D9
    Alternate Names
    • LEM domain containing 5
    • Emery-Dreifuss muscular dystrophy
    背景信息 Emerin is a LEM domain-containing protein found in the nuclear membrane in vertebrates. The LEM domain, a conserved globular domain of approximately 40 amino acids, is present in many nuclear membrane associated proteins. Emerin is known to interact with nuclear lamins, barrier-to-autointegration factor (BAF), nesprin-1 alpha, and a transcription repressor. Functionally, this protein mediates membrane anchorage to the cytoskeleton, stabilizes and promotes formation of the nuclear actin cortical network, and inhibits beta-catenin activity by preventing nuclear accumulation. Mutations to emerin result in Dreifuss-Emery muscular dystrophy, an X-linked inherited degenerative myopathy. This protein appears to play a role in response to mechanical strain and the control of apoptosis due to strain. Emerin may also play a part in chromosome location and anchoring.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-Emerin Antibody, clone 7D9 (Mouse Monoclonal Antibody) validated in WB, ICC to detect Emerin also known as Emery-Dreifuss muscular dystrophy, LEM domain containing 5.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:50 dilution from a representative lot detected Emerin in normal human muscle cells. Courtesy of Dr. Ian Holt, Wolfson Centre for Inherited Neuromuscular Disease.
    生物信息
    免疫原品种 Full length recombinant protein corresponding to human Emerin.
    克隆 7D9
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000108
    Entrez基因汇总 Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq].
    基因符号
    • emerin
    • EDMD
    • LEMD5
    • STA
    纯化方法 Protein G
    UniProt编号
    • P50402
    UniProt汇总 FUNCTION: Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.

    SUBUNIT STRUCTURE: Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the nuclear inner membrane. Interacts with SUN1 and SUN2 (By similarity). Interacts with ACTB, SPTAN1, F-actin, CTNNB1 and beta-tubulin.

    SUBCELLULAR LOCATION: Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note: Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.

    TISSUE SPECIFICTY: Skeletal muscle, heart, colon, testis, ovary and pancreas.

    PTM: Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.

    INVOLVEMENT IN DISEASE: Defects in EMD are the cause of Emery-Dreifuss muscular dystrophy type 1 (EDMD1) [MIM:310300]. A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.

    Sequence similarities Contains 1 LEM domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected Emerin on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE69,Anti-Emerin Antibody, clone 7D9

上一件merck millipore产品：merck millipore,默克密理博,MABN1028,Anti-COPS8 (CSN8) Antibody, clone EPR5139, rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,HTS098RTA,Ready-to-Assay™ NMU2 Neuromedin U Receptor Frozen Cells


相关产品

merck millipore,默克密理博,06-1295,Anti-CDT1 Antibody merck millipore,默克密理博,06-1295,Anti-CDT1 Antibody

merck millipore,默克密理博,ECM507,QCM Chemotaxis Cell Migration Assay, 24-well (5 µm), fluorimetric merck millipore,默克密理博,ECM507,QCM Chemotaxis Cell Migration Assay, 24-well (5 µm), fluorimetric

merck millipore,默克密理博,AB5168-200UL,Anti-CHAPSYN-110 Antibody merck millipore,默克密理博,AB5168-200UL,Anti-CHAPSYN-110 Antibody

merck millipore,默克密理博,AB1876,Anti-Vascular Endothelial Growth Factor Antibody merck millipore,默克密理博,AB1876,Anti-Vascular Endothelial Growth Factor Antibody

merck millipore,默克密理博,MABN1028,Anti-COPS8 (CSN8) Antibody, clone EPR5139, rabbit monoclonal merck millipore,默克密理博,MABN1028,Anti-COPS8 (CSN8) Antibody, clone EPR5139, rabbit monoclonal

merck millipore,默克密理博,HTS098RTA,Ready-to-Assay™ NMU2 Neuromedin U Receptor Frozen Cells merck millipore,默克密理博,HTS098RTA,Ready-to-Assay™ NMU2 Neuromedin U Receptor Frozen Cells

merck millipore,默克密理博,AB3874,Anti-SENP2 Antibody merck millipore,默克密理博,AB3874,Anti-SENP2 Antibody

merck millipore,默克密理博,182540,Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem merck millipore,默克密理博,182540,Aromatase Inhibitor I - CAS 331684-05-0 - Calbiochem

merck millipore,默克密理博,05-23-4904,PKC Inhibitor Peptide 19-31 merck millipore,默克密理博,05-23-4904,PKC Inhibitor Peptide 19-31

merck millipore,默克密理博,04-455,Anti-CD20 (CT) Antibody, rabbit monoclonal merck millipore,默克密理博,04-455,Anti-CD20 (CT) Antibody, rabbit monoclonal


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部