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品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 AB3874 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-SENP2 Antibody Alternate Names - Sentrin/SUMO-specific Protease 2
产品信息 格式 Purified 控制 - POSITIVE CONTROL: Jurkat or NIH3T3 whole cell lysate.
演示 Immunoglobulin was purified by protein G affinitychromatography and is presented as a liquid in PBS with 0.09% sodium azide. 应用 应用 This Anti-SENP2 Antibody is validated for use in ELISA, WB for the detection of SENP2. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1:500 (approximately 69 kDa)
ELISA: 1:1,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to amino acid residues 16-32 of human SENP2
(CDRSVPPARALLKRRRS).浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes human SENP2. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_021627.2
Entrez基因汇总 SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM] 基因符号 - EC 3.4.22.-
- SENP2
- AXAM2
- SMT3IP2
- Axam2
- Smt3ip2
- KIAA1331
- DKFZp762A2316
UniProt编号 - Q9HC62
UniProt汇总 FUNCTION: SwissProt: Q9HC62 # Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity).
SIZE: 589 amino acids; 67855 Da
SUBUNIT: Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus.
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
DOMAIN:SwissProt: Q9HC62 The N-terminus is necessary and sufficient for nuclear envelope targeting.
PTM: Polyubiquitinated; which leads to proteasomal degradation.
SIMILARITY: Belongs to the peptidase C48 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20ºC in undiluted aliquots for up to one year from date of receipt. 包装信息 数量 100 µg
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