merck millipore,默克密理博,MABE525,Anti-RRM1, clone EPR8482, Rabbit Monoclonal Antibody

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merck millipore,默克密理博,MABE525,Anti-RRM1, clone EPR8482, Rabbit Monoclonal Antibody
产品名称：Anti-RRM1, clone EPR8482, Rabbit Monoclonal Antibody
产品型号：MABE525
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.

merck millipore,默克密理博,MABE525,Anti-RRM1, clone EPR8482, Rabbit Monoclonal Antibody

产品介绍

merck millipore,默克密理博,MABE525,Anti-RRM1, clone EPR8482, Rabbit Monoclonal Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	IHC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABE525
描述	Anti-RRM1, clone EPR8482, Rabbit Monoclonal Antibody
Alternate Names	Ribonucleotide reductase large subunit Ribonucleoside-diphosphate reductase large subunit Ribonucleoside-diphosphate reductase subunit M1
背景信息	Ribonucleoside-diphosphate reductase large subunit, or alternatively Ribonucleoside-diphosphate reductase subunit M1, or just Ribonucleotide reductase large subunit and encoded by the human gene named RRM1/RR1 is part of the critical enzyme that catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Cytoplasmically localized and ubiquitously expressed, the enzyme is under complex and tight regulation by its substrates. RRM1 has both activation and specificity binding sites and requires ATP to operate. The binding of the ribonucleotide at the specificity site determines the specificity of the activity. RRM1 operates to create all of the four deoxynucleoside triphosphates. RRM1’s activity level is tied to cell growth and proliferation rates and is up regulated in most cancerous tumors and its expression is used as a biomarker.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:250-500 dilution from a representative lot detected RRM1 in human placenta tissue. Produced in collaboration with Epitomics™

生物信息
免疫原品种	Synthetic peptide corresponding to human RRM1.
克隆	EPR8482
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
同种型	IgG
品种反应性	MouseHuman
Species Reactivity Note	Human, Mouse
抗体类型	Monoclonal Antibody
基因符号	RR1 RRM1
纯化方法	Unpurified
UniProt编号	P23921

产品使用声明
质量保证	Evaluated by Western Blotting in HeLa, HT-29, Raw 264.7, and NIH/3T3 cell lysates. Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected RRM1 in HeLa, HT-29, Raw 264.7, and NIH/3T3 cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.