merck millipore,默克密理愽
  • merck millipore,默克密理博,343021,Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

  • merck millipore,默克密理博,343021,Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

    产品名称：Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem
    产品型号：343021
    The Flt-3 Inhibitor II, also referenced under CAS 896138-40-2, controls the biological activity of Flt-3.

    merck millipore,默克密理博,343021,Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,343021,Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₁₂N₂O₃896138-40-2
    描述
    概述 A cell-permeable symmetrical indolylmethanone kinase inhibitor that is more selective toward Flt3 over PDGFR either in cell-based receptor autophosphorylation (IC50 = 40 nM vs. 300 nM) or in cell-free kinase reactions (IC50 = 33 nM vs. 171 nM) and potently induces apoptosis in Flt3-expressing primary AML patient blasts. Affects Abl- or Kit-dependent cell growth only at much higher concentrations (IC50 = 4.2 and ≥0.5 µM, respectively), while exhibiting little effect against IL-3-mediated cellular signaling. The molecular mechanism of inhibition is presumably due to interaction at the enzyme's ATP-binding site.
    产品目录编号 343021
    品牌系列 Calbiochem®
    同义词 Bis-(5-hydroxy-1H-indol-2-yl)methanone, PDGFR Tyrosine Kinase Inhibitor XI
    参考
    参考 Mahboobi, S., et al. 2006. J. Med. Chem. 49, 3101.
    产品信息
    CAS号 896138-40-2
    具有ATP竞争性 N
    形式 Yellowish brown solid
    Hill配方 C₁₇H₁₂N₂O₃
    化学配方 C₁₇H₁₂N₂O₃
    Molar Mass 292.3
    可逆 N
    结构配方图像
    生物信息
    主靶 Flt-3
    主靶IC50 40 nM against Flt3 in cell-based receptor autophosphorylation; 33 nM against Flt3 in cell-free kinase reactions
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,343021,Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,S7117,ApopTag Plastic Coverslip
下一件merck millipore产品：merck millipore,默克密理博,1690-OP,OmniPur Acrylamide Bis-acrylamide, 29:1, 40% Solution - Calbiochem


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