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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABC62 描述 Anti-DRAM1 Antibody Alternate Names - Damage-regulated autophagy modulator
- DNA damage-regulated autophagy modulator protein 1
背景信息 DNA damage regulated autophagy modulator 1 (DRAM1) is a lysosomal protein used by p53 to regulate macroautophagy. DRAM1 is necessary for p53-mediated apoptosis. DRAM1 is often found to be under-expressed in many tumor types. DRAM1 has also been found to be regulated by p73. 产品信息 格式 Purified 控制 - Human placenta tissue lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect DRAM1 using this Anti-DRAM1 Antibody validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:400 dilution from a representative lot detected DRAM1 in normal human placental villi. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human DRAM1. 克隆 16F3.1 宿主 Mouse 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_060840
Entrez基因汇总 Summary: This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq]. 基因符号 - DRAM
- DRAM1
纯化方法 Protein G Purified UniProt编号 - Q8N682
UniProt汇总 FUNCTION: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein.
INDUCTION: By p53/TP53 and TP73/p73. Directly activated by p53/TP53. Significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing.
SEQUENCE SIMILARITIES: Belongs to the DRAM/TMEM150 family.
SEQUENCE CAUTION: The sequence BAA92091.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Western Blot in human placenta tissue lysate.
Western Blot Analysis: A 1:2,000 dilution of this antibody detected DRAM1 in 10 µg of human placenta tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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