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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, FC M Purified Monoclonal Antibody 描述 产品目录编号 CBL561 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD24 Antibody, clone SN3 Alternate Names - HAS
- Heat Stable Antigen
产品信息 格式 Purified 演示 Affinity purified immunoglobulin by Protein G chromatography. Liquid in 1 mL of PBS, pH 7.4 containing no preservatives. 应用 应用 Anti-CD24 Antibody, clone SN3 detects level of CD24 & has been published & validated for use in FC, IP, IH. 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Immunocytochemistry on frozen tissue sections.
Flow Cytometry: 1:50 - 1:100 per 10e6 cells in 100 μL final volume.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Glycoproteins purified from human NALM-1 cell line. 克隆 SN3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody reacts with the CD24 antigen a heavily glycosylated molecule that migrates as a broad band of 35-45 kDa on both reducing and non-reducing SDS gel electrophoresis. CD24 is attached to the cell membrane via a glycosyl phosphatidylinositol (GPI) anchor and is expressed at multiple stages of B cell development, beginning with the bone marrow CD34 positive pro-B cell compartment and continuing through mature surface IgM positive/IgD positive B cells. CD24 is also expressed on the vast majority of B-lineage acute lymphoblastic leukaemias, B cell chronic lymphocytic leukaemias and B cell non-Hodgkin's lymphoma. In the normal spleen, mantle zone lymphocytes are CD24 strongly positive, but germinal center cells are CD24 negative or CD24 weakly positive. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_013230.2
Entrez基因汇总 This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 3p26, 15q21, 15q22, 20q11.2 and Yq11.1. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined. 基因符号 - CD24A
- CD24
UniProt编号 - P25063
UniProt汇总 FUNCTION: SwissProt: P25063 # Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
SIZE: 80 amino acids; 8097 Da
SUBUNIT: Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K562 and in Burkitt's lymphoma.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
TISSUE SPECIFICITY: B-cells. Expressed in a number of B-cell lines including P32/SH and Nawalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
PTM: Extensively O-glycosylated.
DISEASE: SwissProt: P25063 # Genetic variations in CD24 are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.
SIMILARITY: SwissProt: P25063 ## Belongs to the CD24 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C for up to 12 months from date of receipt in undiluted aliquots. 包装信息 数量 100 µg
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