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merck millipore,默克密理博,AB3713,Anti-phospho Stargazin (Ser239/Ser240) Antibody
产品名称：Anti-phospho Stargazin (Ser239/Ser240) Antibody
产品型号：AB3713
This Anti-phospho Stargazin (Ser239/Ser240) Antibody is validated for use in WB for the detection of phospho Stargazin (Ser239/Ser240).
merck millipore,默克密理博,AB3713,Anti-phospho Stargazin (Ser239/Ser240) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 B, M, R, Rb, Op, Rhesus Macaque, Ca WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB3713 描述 Anti-phospho Stargazin (Ser239/Ser240) Antibody Alternate Names - voltage-dependent calcium channel gamma-2 subunit
- calcium channel, voltage-dependent, gamma subunit 2
- Neuronal voltage-gated calcium channel gamma-2 subunit
背景信息 Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state.
There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival.产品信息 格式 Affinity Purified 控制 - Mouse brain tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-phospho Stargazin (Ser239/Ser240) Antibody is validated for use in WB for the detection of phospho Stargazin (Ser239/Ser240). 主要应用 - Western Blotting
应用说明 Western Blot (SNAP ID) Analysis: 5 µg/mL from a previous lot detected Stargazin on 10 µg of mouse brain tissue lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of mouse Stargazin. 表位 Cytoplasmic domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Stargazin at the cytoplasmic domain. 品种反应性 BovineMouseRatRabbitOpossumRhesus MacaqueCanine Species Reactivity Note Demonstrated to react with mouse and rat. Predicted to react with rabbit, opossum, rhesus monkey, canine, and bovine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_031609
基因符号 - stargazin
纯化方法 Affinity purified UniProt编号 - O88602
UniProt汇总 FUNCTION: Thought to stabilize the calcium channel in an inactivated (closed) state.
SUBUNIT STRUCTURE: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Brain.
PTM: Phosphorylation of Thr-321 by PKA impairs interaction with DLG1 and DLG4.
INVOLVEMENT IN DISEASE: Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.
SEQUENCE SIMILARITIES: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.产品使用声明 质量保证 Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Stargazin on 10 µg of mouse brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,172060,Andrographolide - CAS 5508-58-7 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,05-23-2005,Neuropeptide Y, Human - CAS 90880-35-6 - Calbiochem
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