merck millipore,默克密理愽
  • merck millipore,默克密理博,MABC18,Anti-RalA-binding protein 1 (RalBP1) Antibody, clone 17C11.1

  • merck millipore,默克密理博,MABC18,Anti-RalA-binding protein 1 (RalBP1) Antibody, clone 17C11.1

    产品名称：Anti-RalA-binding protein 1 (RalBP1) Antibody, clone 17C11.1
    产品型号：MABC18
    Anti-RalA-binding protein 1 (RalBP1) Antibody, clone 17C11.1 detects level of RalA-binding protein 1 (RalBP1) & has been published & validated for use in WB.

    merck millipore,默克密理博,MABC18,Anti-RalA-binding protein 1 (RalBP1) Antibody, clone 17C11.1

  • 产品介绍
  • merck millipore,默克密理博,MABC18,Anti-RalA-binding protein 1 (RalBP1) Antibody, clone 17C11.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABC18
    描述 Anti-RalA-binding protein 1 (RalBP1) Antibody, clone 17C11.1
    Alternate Names
    • 76 kDa Ral-interacting protein
    • ralA binding protein 1
    • DNP-SG ATPase
    • Ral-interacting protein 1
    • ralA-binding protein 1
    • Dinitrophenyl S-glutathione ATPase
    背景信息 RalA-binding protein 1 (RalBP1) is a part of a family of small GTPases that are shown to be activated by Ras. RalBP1 activity may be controlled by PKC-alpha-mediated phosphorylation and it is thought to be a key LTC(4) transporter in cancer cells. It has been shown that RalBP1 is an effector of R-Ras and in turn has a role to play in regulation of cell proliferation, migration and apoptosis. RalBP1 has also been implicated in mediating drug-resistance in certain cancers, such as lung. It has been thought of as a potential target in treating leukemia. RalBP1 expression is essential for human cancer cell metastasis.
    产品信息
    格式 Purified
    控制
    • Raji cell lysate
    演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
    应用
    应用 Anti-RalA-binding protein 1 (RalBP1) Antibody, clone 17C11.1 detects level of RalA-binding protein 1 (RalBP1) & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human RalA-binding protein 1.
    克隆 17C11.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgMκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_006779
    Entrez基因汇总 RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM].
    基因符号
    • RalBP1
    • RALBP1
    • RLIP1
    • RLIP76
    • RIP1
    • RIP
    纯化方法 Ion Exchange
    UniProt编号
    • Q15311
    UniProt汇总 FUNCTION: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.

    SUBUNIT STRUCTURE: Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.

    SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein

    TISSUE SPECIFICITY: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.

    SEQUENCE SIMILARITIES: Contains 1 Rho-GAP domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in Raji cell lysate.

    Western Blot Analysis: 2 µg/mL of this antibody detected RalA-binding protein 1 in 10 µg of Raji cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABC18,Anti-RalA-binding protein 1 (RalBP1) Antibody, clone 17C11.1

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下一件merck millipore产品：merck millipore,默克密理博,658452,AG 126 - CAS 118409-62-4 - Calbiochem


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