merck millipore,默克密理愽
  • merck millipore,默克密理博,382170,Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem

  • merck millipore,默克密理博,382170,Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem

    产品名称：Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem
    产品型号：382170
    The Histone Deacetylase Inhibitor IV, also referenced under CAS 537034-15-4, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure More>>

    merck millipore,默克密理博,382170,Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,382170,Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₂₃N₃O₂537034-15-4
    描述
    概述 A cell-permeable pimeloylanilide compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedreich's ataxia) cells (~3-fold increase of FXN mRNA at 5 µM in primary FRDA lymphocytes and ~3-fold frataxin expression in FRDA cell line at 2.5 µM) due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K5 and H4K12, without significant changes in acetylation at H3K9, H4K8 and H4K16. In comparison, Trichostatin-A (Cat. No. 647925 and 647926) and SAHA, two other commonly used HDAC inhibitors, exhibit no effect on FXN transcription.
    产品目录编号 382170
    品牌系列 Calbiochem®
    同义词 N¹-(2-Aminophenyl)-N⁷-phenylheptanediamide
    参考
    参考 Herman, D., et al. 2006. Nat. Chem. Biol. 2, 551.
    产品信息
    CAS号 537034-15-4
    具有ATP竞争性 N
    形式 Beige solid
    Hill配方 C₁₉H₂₃N₃O₂
    化学配方 C₁₉H₂₃N₃O₂
    Molar Mass 325.4
    可逆 N
    结构配方图像
    生物信息
    主靶 Histone Deacetylase
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,382170,Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,539747,InhibitorSelect™ 96-Well Tyrosine Kinase and Phosphatase Inhibitor Library IV - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,ABN527,Anti-VAPB Antibody


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