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经验配方 CAS号 C₉H₅ClINO 130-26-7 描述 概述 A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid’s ability to clump together, apparently by trapping the Cu2+ and Zn2+ that stud these deposits. Shown to increase distal dominant axonopathy in animal models. 产品目录编号 233165 品牌系列 Calbiochem®
同义词 5-Chloro-7-iodo-8-hydroxyquinoline 参考 参考 Melov, S. 2002. Trends Neurosci. 25, 121.
Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord. 12, 408.
Helmuth, L., et al. 2000. Science 290, 1273.
Tateishi, J., et al. 2000. Neuropathology 20, Suppl: S20-4.产品信息 CAS号 130-26-7 具有ATP竞争性 N 形式 Solid Hill配方 C₉H₅ClINO 化学配方 C₉H₅ClINO Molar Mass 305.5 可逆 N 结构配方图像 生物信息 主靶 Metal ion chelator 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO, EtOH or MeOH GHS安全信息 RTECS VC5075000 安全信息 R相 R: 42/43-63
May cause sensitization by inhalation and skin contact.
Possible risk of harm to the unborn child.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Toxic & Carcinogenic / Teratogenic
有害材料注意事项: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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