merck millipore,默克密理愽
  • merck millipore,默克密理博,658452,AG 126 - CAS 118409-62-4 - Calbiochem

  • merck millipore,默克密理博,658452,AG 126 - CAS 118409-62-4 - Calbiochem

    产品名称：AG 126 - CAS 118409-62-4 - Calbiochem
    产品型号：658452
    A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.

    merck millipore,默克密理博,658452,AG 126 - CAS 118409-62-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,658452,AG 126 - CAS 118409-62-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₀H₅N₃O₃118409-62-4
    描述
    概述 A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 15.38 µM).
    产品目录编号 658452
    品牌系列 Calbiochem®
    同义词 α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
    参考
    参考 Cuzzocrea, S., et al. 2000. Am. J. Pathol. 157, 145.
    Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138.
    Kan, H., et al. 1996. Mol. Pharmacol. 50, 1139.
    Novogrodsky, A., et al. 1994. Science 264, 1319.
    产品信息
    CAS号 118409-62-4
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₁₀H₅N₃O₃
    化学配方 C₁₀H₅N₃O₃
    Molar Mass 215.2
    可逆 N
    结构配方图像
    生物信息
    主靶 COX-2 activity
    主靶IC50 15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMF or DMSO
    安全信息
    R相 R: 23/24/25

    Toxic by inhalation, in contact with skin and if swallowed.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Toxic
    有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

    merck millipore,默克密理博,658452,AG 126 - CAS 118409-62-4 - Calbiochem

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