merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB443,Anti-Estrogen Receptor Antibody, clone AER304

  • merck millipore,默克密理博,MAB443,Anti-Estrogen Receptor Antibody, clone AER304

    产品名称：Anti-Estrogen Receptor Antibody, clone AER304
    产品型号：MAB443
    Anti-Estrogen Receptor Antibody, clone AER304 is a Mouse Monoclonal Antibody for detection of Estrogen Receptor also known as ER & has been validated in EMSA, IP, WB & IHC.

    merck millipore,默克密理博,MAB443,Anti-Estrogen Receptor Antibody, clone AER304

  • 产品介绍
  • merck millipore,默克密理博,MAB443,Anti-Estrogen Receptor Antibody, clone AER304

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, B, Ch, HIHC, EMSA, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB443
    Replaces 04-227
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Estrogen Receptor Antibody, clone AER304
    Alternate Names
    • ER
    产品信息
    格式 Ascites
    演示 Liquid
    应用
    应用 Anti-Estrogen Receptor Antibody, clone AER304 is a Mouse Monoclonal Antibody for detection of Estrogen Receptor also known as ER & has been validated in EMSA, IP, WB & IHC.
    主要应用
    • Immunohistochemistry
    • Electrophoretic Mobility Shift Assay
    • Western Blotting
    应用说明 Western blot (human)

    Immunoprecipitation (human)

    Immunohistochemistry (mouse)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Bovine estrogen receptor.
    表位 a.a. 120-170
    克隆 AER304
    宿主 Mouse
    特异性 Estrogen receptor 67kD hormone binding subunit. Epitope localized between aa 120-170.
    同种型 IgG1
    品种反应性 MouseBovineChickenHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000125.2
    Entrez基因汇总 This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
    基因符号
    • DKFZp686N23123
    • ESR1
    • ER-alpha
    • ESR
    • Era
    • ER
    • NR3A1
    • ESRA
    UniProt编号
    • P03372
    UniProt汇总 FUNCTION: SwissProt: P03372 # Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
    SIZE: 595 amino acids; 66216 Da
    SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with JARID1A. Interacts with SMARD1. Interacts with SLC30A9 (By similarity). Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1.
    SUBCELLULAR LOCATION: Nucleus.
    DOMAIN: SwissProt: P03372 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
    PTM: Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
    SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
    MISCELLANEOUS: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone- receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB443,Anti-Estrogen Receptor Antibody, clone AER304

上一件merck millipore产品：merck millipore,默克密理博,MABC547,Anti-Poly ADP-ribose Antibody, clone 10H
下一件merck millipore产品：merck millipore,默克密理博,331569,Ethidium Bromide Adsorber - CAS 69011-20-7 - Calbiochem


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