merck millipore,默克密理愽
  • merck millipore,默克密理博,14-730,c-Kit (V560G) Protein, active, 10 µg

  • merck millipore,默克密理博,14-730,c-Kit (V560G) Protein, active, 10 µg

    产品名称：c-Kit (V560G) Protein, active, 10 µg
    产品型号：14-730
    Active, N-terminal GST tagged recombinant human c-Kit, amino acids 544 -end, containing the V560G mutation, found in patients with gastrointestinal stromal tumours. For use in Kinase Assays.

    merck millipore,默克密理博,14-730,c-Kit (V560G) Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-730,c-Kit (V560G) Protein, active, 10 µg

    描述
    产品目录编号 14-730
    品牌系列 Upstate
    商名
    • Upstate
    描述 c-Kit (V560G) Protein, active, 10 µg
    概述 N-terminal GST tagged recombinant human c-Kit, amino acids 544 - end, containing the V560G mutation. The V560G mutation has been found in patients with gastrointestinal stromal tumours and has been linked to poor prognosis. This mutation confers increased susceptibility to Gleevec®.
    Alternate Names
    • CD117
    • Mast/stem cell growth factor receptor
    • SCFR
    产品信息
    演示 Presented as a frozen solution in 50mM Tris/HCl pH 7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij 35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, and 0.1% 2-mercaptoethanol.
    应用
    应用 Active, N-terminal GST tagged recombinant human c-Kit, amino acids 544 -end, containing the V560G mutation, found in patients with gastrointestinal stromal tumours. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Human c-Kit (V560G) expressed in Sf21 insect cells.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_001093772.1
    • NM_000222.2
    Entrez基因汇总 This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • c-kit
    • KIT
    • C-Kit
    • PBT
    • CD117
    • SCFR
    蛋白靶 c-Kit
    纯化方法 Glutathione-agarose
    靶子系列 TK
    UniProt编号
    • P10721
    UniProt汇总 FUNCTION: SwissProt: P10721 # This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).
    SIZE: 976 amino acids; 109865 Da
    SUBUNIT: Interacts with APS. Interacts with the tenth PDZ domain of MPDZ.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DISEASE: SwissProt: P10721 # Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. & Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. & Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
    SIMILARITY: SwissProt: P10721 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of 250μM GGMEDIYFEFMGGKKK.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 6 months at -70°C from date of shipment. Upon first use, rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-730,c-Kit (V560G) Protein, active, 10 µg

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