merck millipore,默克密理愽
  • merck millipore,默克密理博,14-557M,B-Raf (V599E) Protein, active, 250 µg

  • merck millipore,默克密理博,14-557M,B-Raf (V599E) Protein, active, 250 µg

    产品名称：B-Raf (V599E) Protein, active, 250 µg
    产品型号：14-557M
    Active, N-terminal GST-tagged recombinant human B-Raf residues 416-end, containing a V599E mutation, for use in Kinase Assays.

    merck millipore,默克密理博,14-557M,B-Raf (V599E) Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-557M,B-Raf (V599E) Protein, active, 250 µg

    描述
    产品目录编号 14-557M
    品牌系列 Upstate
    商名
    • Upstate
    描述 B-Raf (V599E) Protein, active, 250 µg
    概述 N-terminal GST-tagged recombinant human B-Raf residues 416-end, containing a V599E mutation (also designated V600E)
    应用
    应用 Active, N-terminal GST-tagged recombinant human B-Raf residues 416-end, containing a V599E mutation, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_004333.3
    基因符号
    • B-RAF V600E
    • BRAF
    • BRAF1
    • B-Raf
    • MGC126806
    • RAFB1
    • p94
    • MGC138284
    • B-raf-1
    • BRAF V600E
    蛋白靶 B-Raf
    纯化方法 Glutathione agarose affinity chromatography
    靶子系列 TKL
    UniProt编号
    • P15056
    UniProt汇总 FUNCTION: SwissProt: P15056 # Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron.
    COFACTOR: Binds 2 zinc ions per subunit (By similarity).
    SIZE: 766 amino acids; 84437 Da
    SUBUNIT: Interacts with RIT1 (By similarity).
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Brain and testis.
    DISEASE: SwissProt: P15056 # Defects in BRAF are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant. & Defects in BRAF are involved in a wide range of cancers. & Defects in BRAF are involved in lung cancer [MIM:211980]. & Defects in BRAF are involved in non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss. & Defects in BRAF may be a cause of colorectal cancer (CRC) [MIM:114500].
    SIMILARITY: SwissProt: P15056 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain. & Contains 1 RBD (Ras-binding) domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of MBP substrate in vitro
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-557) and in bulk (cat# 14-557-K).

    merck millipore,默克密理博,14-557M,B-Raf (V599E) Protein, active, 250 µg

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