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merck millipore,默克密理博,506121,p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem
产品名称：p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem
产品型号：506121
The p38 MAP Kinase Inhibitor III, also referenced under CAS 581098-48-8, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Depho More>>
merck millipore,默克密理博,506121,p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₃H₂₁FN₄S 581098-48-8 描述 概述 A cell-permeable methylsulfanylimidazole compound that acts as a potent, selective, reversible, and ATP-competitive p38 MAP kinase inhibitor (IC50 = 0.38 µM for p38α). Shown to effectively suppresses LPS-induced cytokine release both in vitro (IC50 = 0.16 and 0.039 µM for TNF-α and IL-1β release, respectively, in human PBMC) and in vivo (ED50 = 1.33 mg/kg for TNF-α release in mouse). When compared with SB 203580 (Cat. No. 559389 and 559398), it exhibits reduced inhibitory activity against cytochrome P450-2D6 isoform and, therefore, is better suited for in vivo use. A 10 mM (1 mg/247 µl) solution of p38 MAP Kinase Inhibitor III (Cat. No. 506148) in DMSO is also available. 产品目录编号 506121 品牌系列 Calbiochem®
同义词 ML3403, (RS)-{4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridin-2-yl}-(1-phenylethyl)amine] 参考 参考 Laufer, S.A., et al. 2003. J. Med. Chem. 46, 3230. 产品信息 CAS号 581098-48-8 具有ATP竞争性 Y 形式 Yellow solid Hill配方 C₂₃H₂₁FN₄S 化学配方 C₂₃H₂₁FN₄S Molar Mass 404.5 可逆 Y 结构配方图像 生物信息 主靶 p38 MAP kinase 主靶IC50 0.38 µM for p38 MAP kinase α; 0.16 and 0.039 µM in suppressing LPS-induced TNF-α and IL-1β release, respectively, in human PBMC 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,559303,SANT-1 - CAS 304909-07-7 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,218809,Caspase Substrate Set IV, Fluorogenic - Calbiochem
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