merck millipore,默克密理博,MABN536,Anti-Neuregulin-HBD, Type I/II Antibody, clone N120A/9

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	ICC, WB	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABN536
描述	Anti-Neuregulin-HBD, Type I/II Antibody, clone N120A/9
Alternate Names	Sensory and motor neuron-derived factor Pro-neuregulin-1, membrane-bound isoform Pro-NRG1 Neuregulin-1 Acetylcholine receptor-inducing activity ARIA Breast cancer cell differentiation factor p45 Glial growth factor Heregulin HRG Neu differentiation factor
背景信息	Neuregulin isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9). Neuregulin Type I/II serve as direct ligands for ERBB3 and ERBB4 tyrosine kinase receptors that regulate development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Type I isoforms are the predominant forms expressed in the endocardium. Type II is the major form in skeletal muscle cells, and is expressed in the spinal cord, brain, adult heart, placenta, lung, liver, kidney, and pancreas. Neuregulin-HBD refers to the heparin binding domain of Type I/II Neuregulin.

产品信息
格式	Purified
控制	Human kidney tissue lysate
演示	Purified mouse monoclonal IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Detect Neuregulin using this mouse monoclonal antibody, Anti-Neuregulin-HBD, Type I/II Antibody, clone N120A/9 validated for use in western blotting & ICC.
主要应用	Immunocytochemistry Western Blotting
应用说明	Immunocytochemistry Analysis: A representative lot detected Neuregulin-HBD, Type I/II in COS cells expressing Flag-tagged human Neuregulin-HBD (Prof. J. Trimmer, University of California, Davis.).

生物信息
免疫原品种	Recombinant protein corresponding to the extracellular domain of human Neuregulin-HBD, Type I/II.
表位	Extracellular domain
克隆	clone N120A/9
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	This antibody recognizes the extracellular domain of Neuregulin-HBD, Type I/II.
同种型	IgG2a
品种反应性	RatHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_004486
基因符号	SMDF NRG1 GGF HGL HRGA NDF
纯化方法	Protein G purified
UniProt编号	Q02297

产品使用声明
质量保证	Evaluated by Western Blotting in human kidney tissue lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected Neuregulin-HBD, Type I/II in 10 µg of human kidney tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABN536,Anti-Neuregulin-HBD, Type I/II Antibody, clone N120A/9

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